An interventional study of Vagus nerve stimulation via tragus and Sham stimulation via earlobe in Healthy, sponsored by University of Electronic Science and Technology of China. Completed at 1 site in China. Open to participants aged 18 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-12-13.
Sponsored by University of Electronic Science and Technology of China · Not applicable, Interventional, and Treatment
The main aim of the study is to investigate whether the transcutaneous vagus nerve stimulation(tVNS) improves the ability of inhibitory control in an emotional Go-Nogo task.
A randomized, sham-controlled, between-subject design will be employed in this study. A total of 87 healthy subjects will receive either transcutaneous vagus nerve stimulation via tragus or sham stimulation via the earlobe in the left ear. Brain activity and behavioral data for an emotional Go-Nogo task will be recorded and saliva samples will be collected before, during, and after stimulation.
Some personal traits will be assessed using different kinds of questionnaires, such as the State-Trait Anxiety Inventory (STAI), Beck's Depression Inventory(BDI), Autism Spectrum Quotient (ASQ) et al.
University of Electronic Science and Technology of China is the lead sponsor of 112 studies on the registry; 37 are open to participants now.
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Vagus nerve stimulation via tragus
Device: Vagus nerve stimulation via tragus
Sham stimulation via earlobe
Device: Sham stimulation via earlobe
The device will send stimulus intensity of around 0.5mA via tragus in the left ear (based on participants' subjective report), delivered with a pulse width of 0.5 ms at 25 Hz. Stimulation will be active for 30 seconds, followed by a break of 30 seconds.
The device will send stimulus intensity of around 0.5mA via the earlobe in the left ear (based on participants' subjective reports), delivered with a pulse width of 0.5 ms at 25 Hz. Stimulation will be active for 30 seconds, followed by a break of 30 seconds.
The ability of inhibitory control in an emotional Go-Nogo task
Analysis the behavioral and brain data recorded during the task
Time frame: After 30 minutes stimulation
Oxytocin release
Investigating the oxytocin release after taVNS via tragus and earlobe based on saliva samples
Time frame: within 5 minutes after taVNS via tragus and earlobe
Plan to share: No
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This study is completed, as verified in Dec 2023. You cannot join it, but the record below documents what was studied.
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