Precision Medicine in the Treatment of Epilepsy

Browse trials for

• Epilepsy 1,803

Keywords

• epilepsy
• precision medicine
• treatment targets
• biomarkers
• high density EEG
• gut microbiome
• longitudinal
• levetiracetam
• lamotrigine
• neuroimaging
• machine learning
• treatment response
• PET
• MRI
• Psychometrics

Study population

Eligibility criteria

Groups and cohorts

• Healthy Controls

  Healthy volunteers with no pre-existing or current psychiatric, neurological or server somatic illness.

  Drug: Levetiracetam

• Cohort I

  Patients who have a history of only one epileptic seizure.

• Cohort II

  Patients who are newly diagnosed with epilepsy.

  Drug: Levetiracetam Tablets · Drug: Lamotrigine tablet

• Cohort III

  Patients who are newly diagnosed with epilepsy and have an epileptogenic lesion on MRI concordant with seizure semiology and/or EEG.

  Drug: Levetiracetam

Interventions

• DrugLevetiracetam

  Healthy subjects and patients in Cohort III will undergo a 120 min. \[11C\]-UCB-J PET-MR brain scan followed by intravenous administration of levetiracetam after approx. 60 min. in a displacement paradigm. Before, during and after the intervention arterial spin labeling and resting-state functional MRI will be acquired. To measure the radiolabelled tracer's arterial input function, including its radiolabelled metabolites, blood samples will be drawn during the PET scan from an arterial catheter. The selected regions for the primary analyses are the epileptogenic lesion(s) (patients) and the neocortex, hippocampus, entorhinal cortex, fusiform gyrus, dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, orbitofrontal cortex, striatum, anterior cingulate cortex and amygdala. \[11C\]-UCB-J binding, volume of distribution and SV2A occupancy will be quantified by analyzing the PET images with well-validated kinetic models.

  Also known as: [11C]-UCB-J PET-MR scan

• DrugLevetiracetam Tablets

  Patients in Cohort II will be randomized to treatment with an ASM (levetiracetam) in accordance with standard treatment procedures. The patients will enter a 4 weeks titration period receiving increasing doses. During weeks 5-30, patients will enter an evaluation period where the dose can be increased (continued seizures) or decreased (adverse reactions). In cases of unacceptable seizure control and/or intolerable adverse reactions; shift to lamotrigine arm.

  Also known as: Levetiracetam

• DrugLamotrigine tablet

  Patients in Cohort II will be randomized to treatment with an ASM (lamotrigine) in accordance with standard treatment procedures. The patients will enter a 6 weeks titration period receiving increasing doses. During weeks 5-30, patients will enter an evaluation period where the dose can be increased (continued seizures) or decreased (adverse reactions). In cases of unacceptable seizure control and/or intolerable adverse reactions; shift to levetiracetam arm.

  Also known as: Lamotrigine

Primary outcomes

1. Categorical effect of anti-seizure medication (ASM) on treatment outcome (Cohort II-III).

   1) Seizure-free within six months after starting ASM treatment and remained seizure-free for at least one year (last observed seizure within the six months after starting ASM treatment); 2) Seizure-free more than six months after starting ASM treatment and the seizure-free period lasts at least one year; 3) Fluctuations with both seizure-freedom and seizure-relapse; or 4) Never seizure-free for a year at the third- and fifth-year follow-up timepoint.

   Time frame: As change over time from the ASM evaluation period (after 4-7 weeks titration period) to six months, one, three and five years after for patients in cohort II-III.

2. Categorical effect of a second seizure/epilepsy diagnosis for patients in Cohort I.

   The proportion of patients in Cohort I with one epileptic seizure who become diagnosed with epilepsy.

   Time frame: As change over time of epilepsy diagnosis at six months, one, three and five years after inclusion of patients in Cohort I.

Secondary outcomes

1. Continuous treatment outcome using a seizure severity index (Cohort II-III).

   Treatment outcome as percentage change in the Seizure Severity Questionnaire (SSQ).

   Time frame: As a monthly change over time from the ASM evaluation period (after 4-7 weeks titration period) to one, three and five years after for patients in cohort II-III.

2. Continuous treatment outcome rating adverse events (Cohort II-III).

   Treatment outcome as percentage change in the Liverpool Adverse Event Profile (LAEP).

   Time frame: As a monthly change over time from baseline and one, three and five years after inclusion for patients in cohort II-III.

3. Continuous treatment outcome rating impression of change (Cohort II-III).

   Treatment outcome as percentage change in in Patient's Global Impression of Change (PGIC).

   Time frame: As a monthly change over time from the ASM evaluation period (after 4-7 weeks titration period) to one, three and five years after for patients in cohort II-III.

4. A continuous rating of depression diagnosis (Cohort I-III and healthy).

   Percentage change in Major Depression Inventory (MDI).

   Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

5. A continuous rating of depressive symptoms (Cohort I-III and healthy).

   Percentage change in Inventory of Depressive Symptomatology (IDS-SR30).

   Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

6. A continuous rating of specific depressive symptoms associated with neurological disease (Cohort I-III and healthy).

   Percentage change in the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E).

   Time frame: At baseline between groups (HCs and patients) and as a monthly change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

7. Categorical outcome of psychiatric symptoms (Cohort I-III and healthy).

   Psychopathology assessed by WHO International Classification of Diseases 10 (ICD-10) diagnostic classification and a semi-structured psychiatric, clinical interview.

   Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

8. A continuous rating of symptoms of anxiety (Cohort I-III and healthy).

   Percentage change in the Generalized Anxiety Disorder 7-item (GAD-7).

   Time frame: At baseline between groups (HCs and patients) and as a monthly change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

9. Performance in EMOTICOM Emotional Recognition Task (ERT-eyes) (Cohort I-III and healthy).

   Differences between healthy controls and patients in recognizing facial expressions and emotions.

   Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

10. Performance in Rey Auditory Verbal Learning Test (RAVLT) (Cohort I-III and healthy).

    Differences between healthy controls and patients in verbal learning and memory.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

11. Performance in D-KEFS Color-Word Interference Test (Stroop) (Cohort II-III and healthy).

    Differences between healthy controls and patients in executive function.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort II-III.

12. Performance in D-KEFS Verbal Fluency (Fluency) (Cohort II-III and healthy).

    Differences between healthy controls and patients in executive function.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort II-III.

13. A continuous rating of Wechsler Adult Intelligence Scale (WAIS-IV) (Cohort I-III and healthy).

    Differences between healthy controls and patients in IQ and specific index scores measured as percentage change in Wechsler Adult Intelligence Scale (WAIS-IV).

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

14. Performance in Rey Complex Figure Test (RCFT) (Cohort II-III and healthy).

    Differences between healthy controls and patients in visio-spatial learning.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to 1, 3 and 5 years after inclusion for patients in cohort II-III.

15. Performance in Boston Naming Test (BNT) (Cohort II-III and healthy).

    Differences between patient cohorts in word-retrieval.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort II-III.

16. Performance in Trail Making Test A & B (Trail A & B) (Cohort II-III and healthy).

    Differences between patient cohorts in psychomotor speed.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort II-III.

17. A continuous rating of Quality of Life in Epilepsy (QUOLIE-31) (Cohort I-III and healthy).

    Differences between healthy controls and patients in quality of life measured as percentage change in Quality of Life in Epilepsy (QUOLIE-31).

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to 1, 3 and 5 years after inclusion for patients in cohort I-III.

18. A continuous rating of Sheehans Disability Score (SDS) (Cohort I-III and healthy).

    Differences between healthy controls and patients in quality of life measured as percentage change in Sheehans Disability Score (SDS).

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

19. A continuous rating of WHO 5 wellbeing index (WHO-5) (Cohort I-III and healthy).

    Differences between healthy controls and patients in quality of life measured as percentage change in WHO 5 wellbeing index.

    Time frame: At baseline between groups (HCs and patients) and as a monthly change over time from baseline and one, three and five years after inclusion for patients in cohort II-III.

Other outcomes

1. Continuous treatment outcome rating state aggression (Cohort II-III and healthy).

   Treatment outcome as percentage change in the State-Trait Anger Expression Inventory 2 (STAXI-2).

   Time frame: At baseline between groups (HCs and patients) and as a monthly change over time from baseline and one, three and five years after inclusion for patients in cohort II-III.

2. Continuous treatment outcome rating trait aggression (Cohort II-III and healthy).

   Treatment outcome as percentage change in the Aggression Questionnaire (AQ).

   Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort II-III.

3. Continuous treatment outcome as a measure of self-management of epilepsy (Cohort II-III).

   Treatment outcome as percentage change in the Epilepsy Self-management Scale.

   Time frame: As change over time from baseline to one, three and five years after inclusion for patients in cohort II-III.

4. Continuous treatment outcome as a measure of expectations to treatment outcome (Cohort II-III).

   Treatment outcome as percentage change in the Epilepsy Outcome Expectancy Scale.

   Time frame: As change over time from baseline to one, three and five years after inclusion for patients in cohort II-III.

5. Continuous outcome as epilepsy stigmatization (Cohort II-III).

   Percentage change in the Epilepsy Stigmatization Scale.

   Time frame: As change over time from baseline to one, three and five years after inclusion for patients in cohort II-III.

6. A continuous rating of depression (Cohort I-III and healthy).

   Percentage change in the Becks Depression Inventory (BDI).

   Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

7. Continuous outcome of subjective, cognitive complains (Cohort I-III and healthy).

   Percentage change in the self-report Cognitive Complaints in Bipolar Disorder Rating Assesment.(COBRA).

   Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

8. Continuous outcome of perceived stress (Cohort I-III and healthy).

   Percentage change in the Cohen's Perceived Stress Scale (PSS).

   Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

9. Continuous outcome of personality traits (Cohort I-III and healthy).

   Percentage change in NEO Personality Inventory 3 (NEO-FFI-3).

   Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

10. Continuous outcome of the psychological impact of traumatic event (first seizure/epilepsy diagnosis) (Cohort I-III).

    Percentage change in Impact of Event Scale-Revised (IES-R).

    Time frame: As change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

11. Continuous outcome of coping strategies (Cohort I-III and healthy).

    Percentage change in Coping Self-Efficacy Scale (CSES).

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

12. Continuous outcome of sleep quality (Cohort II-III and healthy).

    Percentage change in Pittsburgh Sleep Quality Index (PSQI).

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort II-III.

13. Continuous outcome of negative life events (Cohort II-III and healthy).

    Percentage change in Stressful Life Event scale (SLE).

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort II-III.

14. Genotyping of epilepsy candidate genes at baseline between Cohort I-III and healthy controls.

    Genotyping of epilepsy candidate genes at baseline such as genes involved with GABA-ergic, glutamatergic and dopaminergic neurotransmission, GRIN2A/B, CLDN5, PIGA, PIGV, PIGT, ALDH7A1, PNPO, SLC2A1, PDYN, MTHFR, PCDH7, NRG, BDNF, MMP-2/3, TRKB, SV2A, SYNGAP1, SNAP25, HLA-B\*15:02, HLA-A\*31:01, HLA-A\*11:01, CYP2D6, CYP2C9, CYP2C19, UGT1A1, ABCB1, ABCC1, CLCN4, SCN1-3A, SCN8A, KCNA2, KCNT1, KCNQ2/3, KCNJ10, HCN1A, GABRA1, ASIC1a, AQP4, neuropeptide Y.

    Time frame: At baseline between groups (HCs and patients).

15. Epigenetic changes in Cohort I-III and healthy controls.

    Epigenetic mechanisms and regulation of microRNA, TSC1/2, NPRL2/3, DEPDC5, AK3, MECP2, ARX, SCN2/3/8A, KCNQ3, GABRG2, GABRA1, GABRB2/3.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

16. Gut microbial biomarkers for drug treatment response (Cohort II-III).

    Identify microbial biomarkers between patients with drug failure vs. patients with no drug failure in Cohort II-III.

    Time frame: As change over time from baseline to one year after inclusion for patients in cohort II-III.

17. Baseline gut microbial biomarkers (Cohort II-III and healthy).

    Identify microbial biomarkers between healthy subjects and patients in cohort II-III.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one years after inclusion for patients in cohort II-III.

18. Gut microbial signatures between epilepsy subtypes (Cohort II-III).

    Identify functional microbial signatures between patients in cohort II-III.

    Time frame: As change over time from baseline to one year after inclusion for patients in cohort II-III.

19. Gut microbial signatures for psychiatric symptoms (Cohort II-III).

    Identify functional microbial signatures between patients with and without psychiatric symptoms in cohort II-III.

    Time frame: As change over time from baseline to one year after inclusion for patients in cohort II-III.

20. Changes from baseline to follow-up in intelligence quotient (IQ) and index scores and cerebral synaptic vesicle glycoprotein 2A (SV2A) binding as imaged by [11C]-UCB-J PET (Cohort III and healthy).

    Latent variable construct of \[11C\]-UCB-J binding and IQ measured as percentage change in Wechsler Adult Intelligence Scale (WAIS-IV) and quantification of binding both globally and in primary volumes of interest; neocortex, hippocampus, entorhinal cortex, fusiform gyrus, dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, orbitofrontal cortex, striatum, anterior cingulate cortex and amygdala in patients from cohort III and healthy controls.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort III.

21. Cerebral SV2A binding in patients with cognitive impairment vs. no cognitive impairment imaged by [11C]-UCB-J PET (Cohort III and healthy).

    Latent variable construct of \[11C\]-UCB-J binding between patients without cognitive impairment vs. patients with cognitive impairment in primary volumes of interest; neocortex, hippocampus, entorhinal cortex, fusiform gyrus, dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, orbitofrontal cortex, striatum, anterior cingulate cortex and amygdala in patients from cohort III and healthy controls.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to the development of a potential cognitive dysfunction and one, three and five years after inclusion for patients in cohort III.

22. Cerebral SV2A binding as imaged by [11C]-UCB-J PET (Cohort III and healthy).

    Latent variable construct of \[11C\]-UCB-J binding both globally and in primary volumes of interest; neocortex, hippocampus, entorhinal cortex, fusiform gyrus, dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, orbitofrontal cortex, striatum, anterior cingulate cortex and amygdala in patients and healthy controls.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort III.

23. Cerebral SV2A binding between drug failure vs. no drug failure as imaged by [11C]-UCB-J PET (Cohort III).

    Latent variable construct of \[11C\]-UCB-J binding and SV2A occupancy in the epileptogenic lesion(s) in patients with drug failure vs. no drug failure.

    Time frame: As change over time from baseline to potential drug failure and one, three and five years after inclusion for patients in cohort III.

24. Cerebral SV2A binding between patients with drug resistance vs. no drug resistance as imaged by [11C]-UCB-J PET (Cohort III).

    Latent variable construct of \[11C\]-UCB-J binding and SV2A occupancy in the epileptogenic lesion(s) in patients with drug resistance vs. no drug resistance.

    Time frame: As change over time from baseline to potential drug resistance and one, three and five years after inclusion for patients in cohort III.

25. Cerebral [11C]-UCB-J PET SV2A occupancy and arterial spin labeling following intravenous administration of the ASM levetiracetam (Cohort III and healthy).

    Latent variable construct of the \[11C\]-UCB-J PET SV2A occupancy and arterial spin labeling after a levetiracetam displacement paradigm in healthy controls compared with patients.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to potential drug failure and one, three and five years after inclusion for patients in cohort III.

26. Cerebral [11C]-UCB-J PET SV2A occupancy and arterial spin labeling following intravenous administration of the ASM levetiracetam (Cohort III and healthy).

    Latent variable construct of the \[11C\]-UCB-J PET SV2A occupancy and arterial spin labeling after a levetiracetam displacement paradigm in healthy controls compared with patients.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to potential development of side effects and one, three and five years after inclusion for patients in cohort III.

27. Cerebral [11C]-UCB-J PET SV2A occupancy and resting-state functional connectivity following intravenous administration of the ASM levetiracetam (Cohort III and healthy).

    Latent variable construct of the \[11C\]-UCB-J PET SV2A occupancy and resting-state functional connectivity after a levetiracetam displacement paradigm in healthy controls compared with patients.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to potential drug failure and one, three and five years after inclusion for patients in cohort III.

28. Cerebral [11C]-UCB-J PET SV2A occupancy and resting-state functional connectivity following intravenous administration of the ASM levetiracetam (Cohort III and healthy).

    Latent variable construct of the \[11C\]-UCB-J PET SV2A occupancy and resting-state functional connectivity after a levetiracetam displacement paradigm in healthy controls compared with patients.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to potential development of side effects and one, three and five years after inclusion for patients in cohort III.

29. Cerebral SV2A binding between patients with side effects vs. no side effects as imaged by [11C]-UCB-J PET (Cohort III).

    Latent variable construct of \[11C\]-UCB-J binding and SV2A occupancy in the epileptogenic lesion(s) in patients with side effects vs. no side effects.

    Time frame: As change over time from baseline to potential development of side effects and one, three and five years after inclusion for patients in cohort III.

30. Cerebral SV2A binding in patients with psychiatric symptoms vs. no psychiatric symptoms imaged by [11C]-UCB-J PET (Cohort III and healthy).

    Latent variable construct of \[11C\]-UCB-J binding between patients without psychiatric symptoms vs. patients with psychiatric symptoms in primary volumes of interest; neocortex, hippocampus, entorhinal cortex, fusiform gyrus, dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, orbitofrontal cortex, striatum, anterior cingulate cortex and amygdala in patients from cohort III and healthy controls.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to a potential psychiatric diagnosis and one, three and five years after inclusion for patients in cohort III.

31. Cerebral [11C]-UCB-J PET SV2A occupancy and the plasma concentration of the ASM levetiracetam (Cohort III and healthy).

    Estimation of the occupied SV2A binding sites from the plasma concentration of levetiracetam.

    Time frame: At baseline between groups (HCs and patients).

32. Hippocampal volume is associated with drug failure (Cohort II-III and healthy).

    Structural MRI scans of hippocampus in healthy subjects and patients in cohort II-III.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort II-III.

33. Volume of thalamus and hippocampus is associated with seizure recurrence (Cohort I-III and healthy).

    Structural MRI scans and volume of thalamus and hippocampus.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

34. Cortical thickness is associated with seizure recurrence (Cohort I-III and healthy).

    Structural MRI scans of cortical thickness of precentral gyri, parahippocampal cortex, entorhinal and fusiform gyri, precuneus and frontal gyri.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

35. Volume of amygdala is associated with psychiatric symptoms (Cohort I-III and healthy).

    Structural MRI scans and volume of amygdala.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

36. Cortical thickness is associated with psychiatric symptoms (Cohort I-III and healthy).

    Structural MRI scans and cortical thickness of orbitofrontal cortex.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

37. Within network resting-state functional connectivity (rsfMRI) is associated with seizure recurrence (Cohort I-III and healthy).

    Resting-state functional MRI scans and within network connectivity.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

38. Whole-brain structural connectomics is associated with seizure recurrence (Cohort I-III and healthy).

    Diffusion Tensor MRI scans and structural connectomics.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

39. Structural connectivity is associated with psychiatric symptoms and drug failure (Cohort I-III and healthy).

    Diffusion Tensor MRI scan and structural connectivity between temporal lobe, the limbic system and orbitofrontal cortex (DTI).

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

40. Between network resting-state functional connectivity (rsfMRI) is associated with psychiatric symptoms and drug failure (Cohort I-III and healthy).

    Resting-state functional MRI scans and between the anterior cingulate cortex, between prefrontal-limbic systems, angular gyrus, temporal lobe, precuneus, cerebellum, default mode network and executive control network (rsfMRI).

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

41. High density EEG functional connectivity is associated with seizure recurrence (Cohort I-III and healthy).

    High density EEG functional connectivity in the theta band.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

42. High density EEG functional connectivity is associated with psychiatric symptoms (Cohort I-III and healthy).

    High density EEG functional connectivity in the anterior cingulate cortex.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

43. High density EEG asymmetry and current source is associated with psychiatric symptoms (Cohort I-III and healthy).

    High density EEG and frontal and occipital alpha asymmetry and theta current source density in the anterior cingulate cortex.

    Time frame: At baseline between groups (HCs and patients) and as change over time from baseline to one, three and five years after inclusion for patients in cohort I-III.

Publications

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• Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshe SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014 Apr;55(4):475-82. doi: 10.1111/epi.12550. Epub 2014 Apr 14. PubMed 24730690 ↗
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• Kwan P, Brodie MJ. Effectiveness of first antiepileptic drug. Epilepsia. 2001 Oct;42(10):1255-60. doi: 10.1046/j.1528-1157.2001.04501.x. PubMed 11737159 ↗
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• Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9861-6. doi: 10.1073/pnas.0308208101. Epub 2004 Jun 21. PubMed 15210974 ↗
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Individual participant data

Plan to share: Yes — Via database of Center for Integrated Molecular Brain Imaging (Knudsen et al 2016, NeuroImage) data will be available for the research community upon request and after approval by the scientific board at Neurobiological Research Unit. The data will be stored on a password protected survey system behind secure "firewalls" in accordance with the General Data Protection Regulation (GDPR, Regulation European Union (EU) 2016/679 April 27, 2016) and the Danish Data Protection Act and the regulation (Act No. 502 of 23 May 2018). Potential further processing in other national and international laboratories may occur, yet always in accordance with the GDPR (Regulation EU 2016/679 April 27, 2016) and the Danish Data Protection Act and the regulation (Act No. 502 of 23 May 2018).