ClinicalTrials.gg
CompletedNCT05448248Updated Feb 26, 2024

Multicenter Registry Study Of Cerebral Venous Thrombosis In China (RETAIN-CH)

An observational study in Cerebral Vein Thrombosis and Cerebral Venous Sinus Thrombosis, sponsored by Capital Medical University. Completed at 1 site in China. Per ClinicalTrials.gov, last updated 2024-02-26.

Sponsored by Capital Medical University · Observational

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Study type
Observational
Model
Cohort
Time perspective
Other
Enrollment
3,276
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-13

Among 11 studies in Intracranial Thrombosis with a site in China — 6 open to participants now, 6 under way, 1 of them phase 3. Intracranial Thrombosis · China.

Started
2022
with 1 other
Observational
6 of 11
3 open now
Registered
3rd of 11
by date
Lead sponsor
3 of 11
Capital Medical University

Among the 11 studies in Intracranial Thrombosis with a site in China, this one is one of 2 that started in 2022, is one of 6 observational ones, and was the 3rd registered.

Intracranial Thrombosis

46 studies on the registry are indexed under Intracranial Thrombosis; 15 are open to participants now.

Browse Intracranial Thrombosis studies →

Open to participants now

6 of the 11 studies in Intracranial Thrombosis with a site in China are open now. Recruiting first, the newest first:

1 more — sign in →

All 6 open studies →

A study can be open while its sites in China have not opened yet or have stopped. Only those recruiting at a site in China →

Who these studies take

Of the 14 Intracranial Thrombosis studies recruiting now, 7 (50%) set no upper age limit and 2 (14%) stop at 75 or younger; 2 take children under 18; 1 takes healthy volunteers.

This study: all sexes · no healthy volunteers.

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02

Study summary

This study will investigate the epidemiology, risk factors, diagnostics, treatment, and the long-term prognosis of cerebral venous thrombosis in China.

Read the detailed description

The epidemiology, risk factors, diagnosis and treatment of Cerebral Venous Thrombosis (CVT) in China are still unclear. A retrospective hospital-based study will be conducted at fifty different hospitals across 31 provinces in China. This study will use ICD-10 to search patients diagnosed with CVT between January 1, 2018 and June 15, 2022 across 31 provinces and municipalities of 104 hospitals in China. Risk factors, clinical and radiological findings, treatment and short-term outcomes will be recorded from the hospital record system. Finally, a prospective follow-up will be conducted for all of the patients enrolled above. By combining data collected from retrospective hospital records with the new follow-up, it will be possible to better understand the epidemiology, risk factors, diagnosis, treatment and the long-term prognosis of CVT in China.

03

Conditions studied

  • Cerebral Vein Thrombosis
  • Cerebral Venous Sinus Thrombosis

Keywords

  • Cerebral Venous Sinus Thrombosis
04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients with cerebral venous sinus thrombosis, deep cerebral vein thrombosis and cortical vein thrombosis.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Cerebral venous sinus thrombosis, deep cerebral vein thrombosis and cortical vein thrombosis diagnosed by digital subtraction angiography (DSA), magnetic resonance venography (MRV), computed tomography venography (CTV) or high-resolution magnetic resonance imaging (HR-MRI).

Exclusion criteria

Exclusion Criteria:

  • None of the patient, trustee or immediate family members signed the .
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Observational model
Cohort
Time perspective
Other
Enrollment
3,276 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Favorable clinical outcome (modified Rankin score 0-1)

    Time frame: Baseline to three years

  2. All-cause mortality

    A combination of death form of all causes

    Time frame: Baseline to three years

Secondary outcomes

  1. Recurrence of cerebral venous thrombosis

    Diagnosed by DSA, MRV, CTV or HR-MRI

    Time frame: Baseline to three years

  2. Favorable clinical outcome (modified Rankin score 0-2)

    Time frame: Baseline to three years

  3. Headache after CVT

    Headache Impact Test - 6 score

    Time frame: Baseline to three years

  4. Incidence of hemorrhagic complication

    Extracranial hemorrhage (fall in hemoglobin of 2 gram/dl or more within 48 hours) or intracranial hemorrhage

    Time frame: Baseline to three years

  5. Recanalization rate of cerebral venous system

    Time frame: Baseline to three years

  6. Incidence of epilepsy

    Time frame: Baseline to three years

  7. Incidence of acute ischemic stroke

    Time frame: Baseline to three years

  8. Incidence of pulmonary embolism

    Time frame: Baseline to three years

  9. Psychological distress after CVT

    Population Health Questionnaire (PHQ)-9 score

    Time frame: Baseline to three years

07

Study locations

1 site
  • Xuan Wu Hospital,Capital Medical University
    Beijing, Beijing 100069, China
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Aug 2022 to primary completion in Dec 2023, 16 months.

How these figures are worked out, and which studies are left out of them.

Registered
Jul 2, 2022
First posted
Jul 7, 2022
StartActual
Aug 20, 2022
Primary completionActual
Dec 20, 2023
CompletionActual
Dec 20, 2023
Last update
Feb 26, 2024
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Feb 26, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT05448248
Collaborators
Brain Hospital of Hunan Provincial, The First Affiliated Hospital of Zhengzhou University, The Affiliated Hospital of Xuzhou Medical University, Guizhou Provincial People's Hospital
Responsible party
Ji Xunming,MD,PhD (Capital Medical University, Capital Medical University) — Principal investigator
First posted
Jul 7, 2022
Start date
Aug 20, 2022
Primary completion
Dec 20, 2023
Completion
Dec 20, 2023
Last update
Feb 26, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.

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Discussion

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