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RecruitingNCT05446259DCMUpdated Feb 13, 2026

Degenerative Cervical Myelopathy Repository

An observational study in Cervical Myelopathy, sponsored by Francis Farhadi. Recruiting at 1 site in United States. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2026-02-13.

Sponsored by Francis Farhadi · Observational

From the registry’s dates

  • Started Jul 2022; still recruiting 4 years 2 months later.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
245
Ages
18 Years to 100 Years
Sex
All
01

Study summary

To create a research repository of patients with known degenerative cervical myelopathy (DCM) and a control cohort of subjects who have non-myelopathic spinal disease. This repository will be used to assess functional and/or biological measures that may allow for improved prediction of symptomatic progression and response to treatment in patients with DCM. In addition, this repository will be used to develop a risk assessment scale to accurately predict functional outcomes following operative management of DCM.

02

Conditions studied

  • Cervical Myelopathy
03

In context

Lead sponsor

Francis Farhadi is the lead sponsor of 9 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 100 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

The study population will be those diagnosed with degenerative cervical myelopathy, and those with cervical degenerative disease who do not experience myelopathic symptoms. Participating subjects will be required to sign the approved informed consent.

Inclusion criteria

  • Diagnosis of degenerative cervical myelopathy
  • Diagnosis of cervical degenerative disease without myelopathy

Exclusion criteria

Exclusion Criteria:

  • None outside or diagnostic requirements and age limits.
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
245 participants (estimated)
Target follow-up
2 Years
Patient registry
Yes
Biospecimen retention
Samples with dna

Groups and cohorts

  • DCM group

    Subjects diagnosed with degenerative cervical myelopathy.

    Other: Standard clinical care procedures and outcome measurements.

  • Control group

    Subjects diagnosed with cervical spinal disease without myelopathic symptoms.

    Other: Standard clinical care procedures and outcome measurements.

Interventions

  • OtherStandard clinical care procedures and outcome measurements.

    Standard of care surgical interventions, imaging impressions, laboratory results, and outcome measurements will be collected and analyzed.

06

What researchers measure

Primary outcomes

  1. Data comparison between DCM and control groups

    This study is to determine biomarkers associated with DCM and analyze objective clinical measures to determine more predictable and potentially effective treatments for patients diagnosed with cervical myelopathy.

    Time frame: 2 years

07

Study locations

1 of 1 sites recruiting
  • University of Kentucky
    Lexington, Kentucky 40536, United States
    Recruiting
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 13, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05446259
Lead sponsor
Francis Farhadi
Responsible party
Francis Farhadi (Associate Professor, University of Kentucky) — Sponsor-investigator
First posted
Jul 6, 2022
Start date
Jul 13, 2022
Primary completion
Jun 2027 (estimated)
Completion
May 2028 (estimated)
Last update
Feb 13, 2026

Study contacts

Francis Farhadi, MD, PhD
Contact
francis.farhadi@uky.edu
859-562-0247
Harshit Arora, PhD
Contact
harshit.arora@uky.edu
859-323-4533
Francis Farhadi, MD, PhD
principal investigator · University of Kentucky

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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