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RecruitingNCT05428358MAGIPACUpdated Apr 29, 2026

Incremental Value of Magnetic Resonance Imaging in Selection of Pancreatic Cancer Patients for Surgery

An interventional study of Preoperative MRI in Pancreatic Cancer, Pancreatic Neoplasm and Liver Metastases, sponsored by University of Aarhus. Recruiting at 3 sites in Denmark. Open to participants aged 18 Years to 99 Years. Per ClinicalTrials.gov, last updated 2026-04-29.

Sponsored by University of Aarhus · Not applicable, Interventional, and Diagnostic

From the registry’s dates

  • Started Aug 2022; still recruiting 4 years 1 month later.
Phase
Not applicable
Study type
Interventional
Enrollment
200
Allocation
Not applicable
Ages
18 Years to 99 Years
Sex
All
01

Study summary

The aim of the study is to examine the incremental value of using magnetic resonance imaging (MRI) in addition to computed tomography (CT) in the diagnostic workup of pancreatic cancer patients.

Read the detailed description

The aim of the study is to examine the incremental value of using magnetic resonance imaging (MRI) in addition to computed tomography (CT) in the diagnostic workup of pancreatic cancer patients. We will conduct a nationwide, prospective clinical trial to examine the incremental value of using MRI for identification of liver metastases in pancreatic cancer patients.

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Conditions studied

  • Pancreatic Cancer
  • Pancreatic Neoplasm
  • Liver Metastases

Keywords

  • magnetic resonance imaging
03

In context

Pancreatic Neoplasms

3,235 studies on the registry are indexed under Pancreatic Neoplasms; 899 are open to participants now.

This study's planned enrollment of 200 is above the median of 46 across 2,424 interventional studies indexed under Pancreatic Neoplasms.

Browse Pancreatic Neoplasms studies →

Lead sponsor

University of Aarhus is the lead sponsor of 1,274 studies on the registry; 183 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 99 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Pancreatic cancer patients considered to have a locally resectable or borderline resectable tumor by the local hepato-pancreato-biliary multidisciplinary team board
  • No liver metastases on CT
  • At least 18 years old and able to provide informed consent
  • Expected pancreatic ductal adenocarcinoma based on CT scan

Exclusion criteria

Exclusion criteria:

  • Metastatic disease
  • Prior receipt of neoadjuvant chemotherapy or downstaging/-sizing treatment
  • Comorbidity rendering major surgery unfeasible (inoperable)
  • No informed consent
  • Unable to undergo MRI (Kidney insufficiency (eGFR \< 60 ml/min/1.73 m2 body surface ar-ea); Claustrophobia; Cardiac pacemaker)
  • Postoperative histology other than adenocarcinoma of pancreato-biliary origin.
  • MRI with liver-specific contrast performed during standard workup.
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Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
200 participants (estimated)

Study arms

  • Experimental
    Preoperative MRI

    MRI before surgery.

    Diagnostic Test: Preoperative MRI

Interventions

  • Diagnostic testPreoperative MRI

    Preoperative MRI performed between outpatient visit at the surgical clinic and scheduled date of resection

06

What researchers measure

Primary outcomes

  1. Change in treatment strategy

    Change in treatment strategy from intended curative resection to other treatment based on MRI scan

    Time frame: 1 week

Secondary outcomes

  1. Liver metastases

    Proportion of patients who had liver metastases detected on MRI

    Time frame: 1 week

  2. Surgery

    Proportion of patients who made it to surgery/exploration

    Time frame: 1 month

  3. Resection

    Proportion of patients in each arm who had a pancreatic resection performed

    Time frame: 1 month

  4. Intraoperatively detected liver metastases

    Proportion of patients with intraoperatively detected liver metastases not seen on either CT or MRI.

    Time frame: 1 month

  5. Overall survival (1-year)

    1-year overall survival.

    Time frame: 1 year

  6. Overall survival (3-year)

    3-year overall survival.

    Time frame: 3 years

  7. Recurrence-free survival

    Recurrence-free survival according to final treatment strategy.

    Time frame: 3 years

  8. Healthcare costs

    Healthcare costs in patients with change of treatment.

    Time frame: 3 years

07

Study locations

3 of 3 sites recruiting
  • Aalborg University Hospital
    Aalborg, Denmark
    • Mogens Stender, MD, PhD · Contact
    Recruiting
  • Aarhus University Hospital
    Aarhus, 8200, Denmark
    • Jakob Kirkegård, MD, PhD · Contact · jakob.kirkegaard@auh.rm.dk · +4522900604
    • Frank V Mortensen, MD, DMSc · Contact · frmort@rm.dk · +45222517296
    • Jakob Kirkegård, MD, PhD · Principal investigator
    • Frank V Mortensen, MD, DMSc · Sub investigator
    Recruiting
  • Rigshospitalet
    Copenhagen, Denmark
    • Carsten P Hansen, MD, DMSc · Contact
    Recruiting
08

References and documents

Study documents

  • Protocol and statistical analysis plan · Mar 8, 2023

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: No — Due to Danish law, no individual-level data can be shared.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 29, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05428358
Lead sponsor
University of Aarhus
Collaborators
Rigshospitalet, Denmark, Aalborg University Hospital
Responsible party
Sponsor
First posted
Jun 23, 2022
Start date
Aug 30, 2022
Primary completion
Dec 1, 2027 (estimated)
Completion
Dec 1, 2028 (estimated)
Last update
Apr 29, 2026

Study contacts

Jakob Kirkegård, MD, PhD
Contact
jakob.kirkegaard@auh.rm.dk
+4522900604
Frank Mortensen, MD, DMSc
Contact
frmort@rm.dk
+45222517296
Frank Mortensen, MD, DMSc
study chair · Aarhus University Hospital
Jakob Kirkegård, MD, PhD
principal investigator · Aarhus University Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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