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CompletedNCT05403216Updated Sep 25, 2025

Relationship Between Oral Lichen Planus and Autoimmune Thyroid Diseases

An observational study in Oral Lichen Planus, sponsored by The Dental Hospital of Zhejiang University School of Medicine. Completed at 1 site in China. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-09-25.

Sponsored by The Dental Hospital of Zhejiang University School of Medicine · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
150
Ages
18 Years to 65 Years
Sex
All
01

Study summary

On the basis of previous studies, a validation cohort will be established to explore the relationship between oral lichen planus and autoimmune thyroid diseases, and a disease efficacy prediction strategy can be formed.

Read the detailed description

For oral lichen planus patients, the prevalence of Hashimoto's thyroiditis will be investigated and the relationship between levels of anti-TG, anti-TPO antibodies and severity of oral lichen planus will be determined.

Besides, for patients with Hashimoto's thyroiditis, the prevalence of oral lichen planus will be investigated and the relationship between levels of anti-TG, anti-TPO antibodies and severity of oral lichen planus will be determined.

02

Conditions studied

  • Oral Lichen Planus

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03

In context

Lichen Planus, Oral

139 studies on the registry are indexed under Lichen Planus, Oral; 24 are open to participants now.

This study's enrollment of 150 is above the median of 78 across 35 observational studies indexed under Lichen Planus, Oral.

Browse Lichen Planus, Oral studies →

Lead sponsor

The Dental Hospital of Zhejiang University School of Medicine is the lead sponsor of 25 studies on the registry; 16 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Oral lichen planus (OLP) patients

Inclusion criteria

  • OLP patients without systemic disease

Exclusion criteria

Exclusion Criteria:

  • OLP patients with severe periodontal disease
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
150 participants (actual)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • OLP(-)

    Oral lichen planus (OLP) with negative thyroid antibody group

  • OLP(+)

    OLP with positive thyroid antibody group

    Other: no intervention

Interventions

  • Otherno intervention
06

What researchers measure

Primary outcomes

  1. Oral lichen planus (OLP) lesions record

    Record changes of lesions based on the symptoms and signs of the oral lichen planus patient.

    Time frame: 1 year

  2. Level of thyroid function and antibody

    The levels of thyroid hormone and thyroid autoantibodies in serum of OLP patients were detected.

    Time frame: 1 year

07

Study locations

1 site
  • The Stomatology Hospital, Zhejiang University School of Medicine
    Hangzhou, Zhejiang 310014, China
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 25, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05403216
Lead sponsor
The Dental Hospital of Zhejiang University School of Medicine
Responsible party
Qianming Chen (professor, The Dental Hospital of Zhejiang University School of Medicine) — Principal investigator
First posted
Jun 3, 2022
Start date
Dec 1, 2022
Primary completion
Dec 31, 2024
Completion
Dec 31, 2024
Last update
Sep 25, 2025

Study contacts

Qianming Chen, Dr.
study chair · Zhejiang University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.

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