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Status unknownNCT05390099Updated May 26, 2022

Anti-Plaque and Anti-Gingivitis Effects of Moringa Plant Extract and Fluoride Toothpastes

An interventional study of Moringa oleifera leaf in Oral Disease, sponsored by Cairo University. Status unknown at 1 site in Egypt. Open to participants aged 12 Years to 14 Years. Per ClinicalTrials.gov, last updated 2022-05-26.

Sponsored by Cairo University · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified May 2022), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
12 Years to 14 Years
Sex
All
01

Study summary

The present study aims to assess and compare the anti-plaque and anti-gingivitis effects of Moringa plant extract and Fluoride toothpastes among a group of Egyptian Children.

Read the detailed description

In the last few years, the use of plant extracts in alternative medicine has evolved widely. Various herbal products, including mouthwash and toothpaste, are now available and have been shown to possess a beneficial effect on oral health .Moringa plant is used to treat various diseases including the treatment of the oral cavity or dentistry .

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Conditions studied

  • Oral Disease

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03

In context

Gingivitis

590 studies on the registry are indexed under Gingivitis; 104 are open to participants now.

This study's planned enrollment of 60 is close to the median of 64 across 478 interventional studies indexed under Gingivitis.

Browse Gingivitis studies →

Lead sponsor

Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.

Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
12 Years to 14 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Children of 12-14 years of age.
  • Presence of gingivitis-calculus, and plaque (gingival index [GI]score ≥1/plaque index [PI] score ≥1).
  • Children willing to participate.
  • Children whose parents/caretakers gave informed consent.

Exclusion criteria

Exclusion criteria

  • Children having fixed or removable orthodontic appliances or removable prostheses.
  • Children suffering from any systemic illness.
  • Children who were already using mouthwashes.
  • History of oral prophylaxis within 6 months.
  • Children using any other oral hygiene aids.
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
60 participants (estimated)

Study arms

  • Experimental
    moringa plant toothpaste

    Drug: Moringa oleifera leaf

  • Active comparator
    Fluoride toothpaste

    Drug: Moringa oleifera leaf

Interventions

  • DrugMoringa oleifera leaf

    Moringa toothpaste

06

What researchers measure

Primary outcomes

  1. gingival index (Loe and Sillness, 1963)

    index

    Time frame: 6 weeks

Secondary outcomes

  1. plaque index (Sillness and Loe, 1964)

    index

    Time frame: 6 weeks

07

Study locations

1 of 1 sites recruiting
  • Cairo university
    Giza, Egypt
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 26, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05390099
Lead sponsor
Cairo University
Responsible party
marwa aly fouad elchaghaby (principal investigator, Cairo University) — Principal investigator
First posted
May 25, 2022
Start date
Apr 1, 2022
Primary completion
Jul 1, 2022 (estimated)
Completion
Jul 7, 2022 (estimated)
Last update
May 26, 2022

Study contacts

marwa A elchaghaby, phd
Contact
marwaaly2003@yahoo.com
01006231612
marwa m elchaghaby, phd
principal investigator · marwaaly2003@yahoo.com

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in May 2022. You cannot join it, but the record below documents what was studied.

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