CClinicalTrials.gg
CompletedNCT05367414Updated Jan 29, 2025

Aromatherapy Massage for Itching Management in Liver Diseases

An interventional study of aromatherapy massage (diluted tea tree oil) and aromatherapy massage (sweet almond oil) in Aromatherapy, Massage and Liver Diseases, sponsored by Amine Terzi. Completed at 1 site in Turkey. Open to participants aged 37 Years to 88 Years. Per ClinicalTrials.gov, last updated 2025-01-29.

Sponsored by Amine Terzi · Not applicable, Interventional, and Supportive care

From the registry’s dates

  • Registered 2 years 2 months after the study started (first participant enrolled Feb 2020, registered Apr 2022).
Phase
Not applicable
Study type
Interventional
Enrollment
36
Allocation
Randomized
Ages
37 Years to 88 Years
Sex
All
01

Study summary

The aim of this study is to determine the effect of aromatherapy massage on itching, comfort, skin pH level and skin moisture in individuals with liver disease.

Research Hypotheses:

H1: Aromatherapy massage has an effect on the level of itching in individuals with itchy liver disease.

H2: Aromatherapy massage has an effect on the general comfort level in individuals with itchy liver disease, H3: Aromatherapy massage has an effect on skin pH level in individuals with itchy liver disease.

H4: Aromatherapy massage has an effect on skin moisture in individuals with itchy liver disease.

Read the detailed description

This randomised controlled trial was conducted in order to examine study effect of aromatherapy massage on itching, comfort, skin pH level, and skin moisture among individuals with liver diseases

02

Conditions studied

  • Aromatherapy
  • Massage
  • Liver Diseases
  • Itching
  • PH Level
  • Skin Moisture

Keywords

  • aromatherapy
  • massage
  • liver Diseases
  • itching
03

In context

Liver Diseases

2,081 studies on the registry are indexed under Liver Diseases; 390 are open to participants now.

This study's enrollment of 36 is below the median of 50 across 1,323 interventional studies indexed under Liver Diseases.

Browse Liver Diseases studies →

Lead sponsor

This is the only study on the registry with Amine Terzi as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
37 Years to 88 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • patients who volunteered to participate in the study,
  • with a diagnosis of chronic liver disease (liver cirrhosis (primary biliary cirrhosis, alcoholic, cardiac, post-necrotic, cryptogenic cirrhosis, Wilson's Cirrhosis, hemochromatosis), chronic viral hepatitis),
  • had no cognitive impairment,
  • were not included in the pre-application,
  • could answer questions,
  • itch score of above 3 (with Visual Analogue Scale).

Exclusion criteria

Exclusion Criteria:

  • patients are taking antipruritic treatment,
  • have itchy skin disease before, ulcer, eczema, etc. in the area to be applied
  • patients with dermatological problems, any swelling or signs of inflammation in the area ---to be treated, neuropathy or loss of sensation in the area to be treated
  • patients with allergic to tea tree oil, perfume, or cosmetics,
  • diagnosed with cancer
05

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
36 participants (actual)

Study arms

  • Experimental
    aromatherapy

    In addition to routine medical treatment, massage with diluted tea tree oil was applied to the individuals in this group.

    Other: aromatherapy massage (diluted tea tree oil)

  • Placebo comparator
    placebo

    Individuals in this group were provided massage with sweet almond oil in addition to routine medical treatment.

    Other: aromatherapy massage (sweet almond oil)

  • No intervention
    control

    Individuals in this group received only routine medical treatment.

Interventions

  • Otheraromatherapy massage (diluted tea tree oil)

    massage with diluted tea tree oil was applied

  • Otheraromatherapy massage (sweet almond oil)

    massage with sweet almond oil was applied

06

What researchers measure

Primary outcomes

  1. Itching

    Itching was assessed with the 5D Itch Scale. The total score of the scale ranges from 5 to 25, with 5 points indicating the absence of itching and 25 points indicating the highest severity of itching.

    Time frame: Day 1

  2. Itching

    Itching was assessed with the 5D Itch Scale. The total score of the scale ranges from 5 to 25, with 5 points indicating the absence of itching and 25 points indicating the highest severity of itching.

    Time frame: Day 14

  3. comfort

    Comfort assessed with the General Comfort Scale. The score to be obtained from the scale varies between 48 and 192. 48 points indicating the low comfort level and 192 points indicating the high comfort level.

    Time frame: Day 1

  4. comfort

    Comfort assessed with the General Comfort Scale.The score to be obtained from the scale varies between 48 and 192. 48 points indicating the low comfort level and 192 points indicating the high comfort level.

    Time frame: Day 2

  5. comfort

    Comfort assessed with the General Comfort Scale. The score to be obtained from the scale varies between 48 and 192. 48 points indicating the low comfort level and 192 points indicating the high comfort level.

    Time frame: Day 14

  6. skin pH level

    For pH level measurement, the F-74 G model skin pH measuring device manufactured by HORIBA Scientific and ISFET (Ion Sensitive Field Effect Transistor) 0040-10D model pH electrode produced by HORIBA Scientific were used.

    Time frame: Day 1

  7. skin pH level

    For pH level measurement, the F-74 G model skin pH measuring device manufactured by HORIBA Scientific and ISFET (Ion Sensitive Field Effect Transistor) 0040-10D model pH electrode produced by HORIBA Scientific were used.

    Time frame: Day 2

  8. skin pH level

    For pH level measurement, the F-74 G model skin pH measuring device manufactured by HORIBA Scientific and ISFET (Ion Sensitive Field Effect Transistor) 0040-10D model pH electrode produced by HORIBA Scientific were used.

    Time frame: Day 14

  9. skin moisture level

    DMM brand skin moisture measuring device was used to measure skin moisture level.

    Time frame: Day 1

  10. skin moisture level

    DMM brand skin moisture measuring device was used to measure skin moisture level.

    Time frame: Day 2

  11. skin moisture level

    DMM brand skin moisture measuring device was used to measure skin moisture level.

    Time frame: Day 14

07

Study locations

1 site
  • Artvin Coruh University
    Artvin, Turkey
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 29, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05367414
Lead sponsor
Amine Terzi
Responsible party
Amine Terzi (Asst. Prof., Artvin Coruh University) — Sponsor-investigator
First posted
May 10, 2022
Start date
Feb 13, 2020
Primary completion
May 3, 2021
Completion
Jun 23, 2021
Last update
Jan 29, 2025

Study contacts

Amine TERZI, PHD
principal investigator · Artvin Coruh University
Yasemin YILDIRIM, PHD
study director · Ege University
Fisun SENUZUN AYKAR, PHD
study chair · Izmir Tinaztepe University
Ulus Salih AKARCA, PHD
study chair · Ege University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2022. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion