CClinicalTrials.gg
CompletedNCT05331261Updated Sep 21, 2026

The Effect of Post-Surgery Exercise in Patients With Total Knee Replacement Surgery

An interventional study of Total diz replacement ameliyatı in Pain, Postoperative, sponsored by Alev Keskin. Completed at 2 sites in Turkey (Türkiye). Open to participants aged 18 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-21.

Sponsored by Alev Keskin · Not applicable, Interventional, and Supportive care

Phase
Not applicable
Study type
Interventional
Enrollment
55
Allocation
Not applicable
Ages
18 Years to 90 Years
Sex
All
01

Study summary

postoperative pain; It is acute pain that begins with surgical trauma and decreases during tissue healing. Although it is predictable and treatable, it still seems to be an important problem today. Many researchers in the literature have reported that approximately 50-70% of patients receive inadequate pain treatment after surgery, and many patients complain of moderate or severe pain. Poor control of postoperative pain may cause deep venous thrombosis and delayed wound healing, increased hospital stay, and delayed return to daily life activities. This may negatively affect the quality of life and recovery of patients Therefore, there is a need for methods that increase pain control, such as non-pharmacological methods, to accelerate postoperative recovery. Nurses in postoperative pain management; they help control pain with non-pharmacological methods such as breathing exercises, positioning, relaxation techniques, massage, listening to music, hot application, cold application, and distraction.

Read the detailed description

This study was designed as a quasi-experimental study to examine the effect of breathing exercise on pain in patients undergoing Total Knee Replacement surgery. This exercise is utterly simple, takes almost no time, requires no equipment and can be done anywhere. Although you can do the exercise in any position, sit with your back straight while learning the exercise. Place the tip of your tongue against the ridge of tissue just behind your upper front teeth, and keep it there through the entire exercise. You will be exhaling through your mouth around your tongue; try pursing your lips slightly if this seems awkward.

  • Exhale completely through your mouth, making a whoosh sound.
  • Close your mouth and inhale quietly through your nose to a mental count of four.
  • Hold your breath for a count of seven.
  • Exhale completely through your mouth, making a whoosh sound to a count of eight.
  • This is one breath. Now inhale again and repeat the cycle three more times for a total of four breaths.

This study was designed as a quasi-experimental study to examine the effect of breathing exercise on pain in patients undergoing Total Knee Replacement surgery. Note that you always inhale quietly through your nose and exhale audibly through your mouth. The tip of your tongue stays in position the whole time. Exhalation takes twice as long as inhalation. The absolute time you spend on each phase is not important; the ratio of 4:7:8 is important. If you have trouble holding your breath, speed the exercise up but keep to the ratio of 4:7:8 for the three phases. With practice you can slow it all down and get used to inhaling and exhaling more and more deeply.

This exercise is a natural tranquilizer for the nervous system. Unlike tranquilizing drugs, which are often effective when you first take them but then lose their power over time, this exercise is subtle when you first try it but gains in power with repetition and practice. Do it at least twice a day. You cannot do it too frequently. Do not do more than four breaths at one time for the first month of practice. Later, if you wish, you can extend it to eight breaths. If you feel a little lightheaded when you first breathe this way, do not be concerned; it will pass.

02

Conditions studied

  • Pain, Postoperative

Browse trials for

Keywords

  • Ameliyat sonrası ağrıdan nefes egzersizleri.
03

In context

Pain, Postoperative

5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.

This study's enrollment of 55 is below the median of 75 across 4,344 interventional studies indexed under Pain, Postoperative.

Browse Pain, Postoperative studies →

Lead sponsor

Alev Keskin is the lead sponsor of 3 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • be over the age of 18,

    • Being able to speak Turkish,
    • Does not have any barriers in communication, understanding and comprehension,
    • Not having visual and hearing impairment,
    • Not taking pain medication 60 minutes before or 30 minutes after the intervention,
    • Volunteering to participate in the research,

Exclusion criteria

Exclusion Criteria:

-

05

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
55 participants (actual)

Study arms

  • Experimental
    The Effect of 4-7-8 Breathing Technique on Pain

    Impact of the 4-7-8 Breathing Technique on Postoperative Pain Following Total Knee Arthroplasty

    Procedure: Total diz replacement ameliyatı

Interventions

  • ProcedureTotal diz replacement ameliyatı

    Breath exercises

06

What researchers measure

Primary outcomes

  1. NRS Scale

    NRS is a unidimensional scale that uses 11 numbers (from 0 to 10) to measure pain intensity.32 The patient is asked to choose the number that best reflects their pain intensity (0=no pain at all, 10= the worst pain).

    Time frame: Bir dakika

07

Study locations

2 sites
  • Çukurova Üniversitesi
    Adana, Sarıçam, Turkey (Türkiye)
  • Çukurova Üniversitesi
    Adana, University, Turkey (Türkiye)
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 21, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT05331261
Lead sponsor
Alev Keskin
Responsible party
Alev Keskin (Co-investigator, Cukurova University) — Sponsor-investigator
First posted
Apr 15, 2022
Start date
Apr 20, 2022
Primary completion
May 2, 2023
Completion
May 28, 2023
Last update
Sep 21, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion