An observational study in Cerebrovascular Trauma, sponsored by Poudre Valley Health System. Status unknown. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-03-31.
Sponsored by Poudre Valley Health System · Observational
The goal of this study is to evaluate a series of cases of penetrating cerebrovascular injury managed without upfront operation. Investigators focus on patient characteristics, injury details, treatment modalities, serial imaging studies, patient outcomes, and complications. Investigators will compare this patient population to patients managed with upfront operation for context.
Penetrating cerebrovascular injuries (PCVIs) are uncommon, with little data to guide management when emergent operative repair is not performed. Investigators hypothesized that PCVIs may be managed with antithrombotic therapy and directed use of endovascular interventions, but that PCVIs may require enhanced surveillance due to a risk of delayed complications. To perform this study, investigators will review patients with penetrating carotid and vertebral artery injuries managed at an urban Level I trauma center from 2016 to 2022. Patients will be included if they underwent initial nonoperative management (NOM). Patient characteristics, injury details, treatments, serial imaging, outcomes, and complications will be assessed in a retrospective manner using chart abstraction. Investigators will briefly compare these patients to those managed with upfront operations for context.
Poudre Valley Health System is the lead sponsor of 15 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Investigators are including all adult patients with penetrating cerebrovascular injury since 5/1/2016 to present. Investigators will focus on those managed without operative intervention, but will include cases managed operatively for comparison.
Inclusion Criteria:
PCVI from penetrating trauma without upfront operation
Other: No intervention
Other: No intervention
This study did is a retrospective case series and does not involve an intervention. Investigators will compare patients managed operatively vs nonoperatively, focused on nonoperative therapy.
number of patients with stroke
ischemic stroke
Time frame: up to one year post-injury
number of patients with injury progression
CTA progression of PCVI severity (Grade)
Time frame: up to one year post-injury
number of patients with death
death
Time frame: up to one year post-injury
number of patients with bleeding complications
intracranial hemorrhage, GI bleed, etc requiring change in treatment
Time frame: up to one year post-injury
number of patients treated with operative exploration
All patients in cohort are treated with initial trial of nonoperative management. This outcome assesses the number of patients who subsequently required operative neck exploration. This is readily attainable from operative reports.
Time frame: up to one year post-injury
number of patients treated with arterial embolization or arterial stent placement
IR procedures are adjuncts to nonoperative management. Performance of these procedures is readily attainable from IR procedure reports.
Time frame: up to one year post-injury
No study locations are listed for this record.
Plan to share: No — Data is not readily sharable due to HIPAA restrictions
No publications or documents are linked to this record.
This study is status unknown, as verified in Mar 2022. You cannot join it, but the record below documents what was studied.
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Cerebrovascular Trauma
Poudre Valley Health System