A Phase 3 interventional study of Mifepristone and Letrozole in Miscarriage, sponsored by Calcutta National Medical College and Hospital. Completed at 1 site in India. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-04-02.
Sponsored by Calcutta National Medical College and Hospital · Phase 3, Interventional, and Treatment
Prospective interventional study where participants with non-viable pregnancy at 1st trimester will be randomized into two arms, one group will receive conventional treatment with oral mifepristone followed by misoprostol vaginally and another group will receive letrozole for three consecutive days followed by misoprostol vaginally in an attempt to terminate the pregnancy medically. Mean duration of induction to expulsion of product of conception and rate of complete abortion will be compared in two groups.
320 studies on the registry are indexed under Abortion, Spontaneous; 53 are open to participants now.
This study's enrollment of 120 is below the median of 147 across 174 interventional studies indexed under Abortion, Spontaneous.
Browse Abortion, Spontaneous studies →This is the only study on the registry with Calcutta National Medical College and Hospital as lead sponsor.
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EXCLUSION CRITERIA :
Participants with 1st trimester miscarriage will receive oral 200mg mifepristone . After 48 hours of mifepristone, 800 micro gm misoprostol will be given vaginally for expulsion of product of conception (standard care).
Drug: Mifepristone
Participants with 1st trimester miscarriage will receive 10mg letrozole orally for three consecutive days. This is to be followed by tablet misoprostol 800 micro gm vaginally for expulsion of product of conception (standard care).
Drug: Letrozole
Participants with 1st trimester miscarriage will receive for medical termination
Also known as: Misoprostol 800 microgram vaginally
Participants with 1st trimester miscarriage will receive for medical termination
Also known as: Misoprostol 800 microgram vaginally
Expulsion of product of conception
Mean duration of expulsion since administration of vaginal misoprostol
Time frame: 24 hours since administration of misoprostol
Requirement of surgical evacuation
Surgical evacuation where complete abortion does not occur
Time frame: beyond 24 hours since misoprostol administration
This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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