An Early Phase 1 interventional study of 2L of polyethyleneglycol and inulin in Healthy, sponsored by Yanqing Li. Status unknown. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-03-14.
Sponsored by Yanqing Li · Early Phase 1, Interventional, and Prevention
An adequate bowel preparation is essential for a high quality of colonscopy. Nowdays, polyethyleneglyco is considered the most safe drug for bowel preparation, and is widely used around the world. However, previous study illustrated that bowel preparation by polyethyleneglyco could lead to qualitative changes in the intestinal microbiota both in mice and human. This study is aimed to investigate wether the changes in the intestinal microbiota could lead to a higher rate of intestinal infection.
Exclusion Criteria:
participants take 2L of polyethyleneglycol only
Drug: 2L of polyethyleneglycol
participants take 2L of polyethyleneglycol, subsequently take 15g inulin per day.
Drug: 2L of polyethyleneglycol · Dietary Supplement: inulin
Participants take 2L of polyethyleneglycol, subsequently take 15g probiotics combination product (including Bifidobacterium lactis, Lactobacillus plantarum, inlulin, Vitamin C) per day. The probiotic combination product, named "Mei Ri Yi Jun" was produced by Wedge Pharmaceuticals.
Drug: 2L of polyethyleneglycol · Combination Product: probiotic combination product
2L of polyethyleneglycol
15g inulin per day
participants take 2L of polyethyleneglycol, subsequently take 15g probiotics combination product (including Bifidobacterium lactis, Lactobacillus plantarum, inlulin, Vitamin C) per day. The probiotic combination product, named "Mei Ri Yi Jun" was produced by Wedge Pharmaceuticals.
Polyethyleneglycol could lead to changes in the intestinal flora
People with polyethyleneglycol administration will lead to a decrease of intestinal flora quantity
Time frame: one year(from 15/3/2022 to 15/3/2023)
inulin and probiotics could improve the recovery of gut microbiota
inulin and probiotics will improve the recovery of flora quantity after Polyethyleneglycol administration
Time frame: one year(from 15/3/2022 to 15/3/2023)
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Mar 2022. You cannot join it, but the record below documents what was studied.
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Yanqing Li