A Study of Hepalatide Combined With TAF and PEG-IFN as Finite Treatment of Chronic Hepatitis B Patients

• 1. HBsAg or/and HBV DNA Positive for at least 6 months

     2. HBeAg negative
     3. Received NAs stabilization therapy for at least 2 years
     4. ALT≤ 2×ULN
     5. HBV DNA\< LLQD(lower limit of quantitative detection) in Screening
     6. Serum total bilirubin\<2×ULN
     7. no childbirth plan within 2 years and agree to take effective contraceptive measures throughout the treatment period and within 3 months after the last dose, and that the woman is not pregnant or breastfeeding.
     8. have not participant in another clinical trial within 3 months before screening
     9. Subjects have good compliance with the protocol
     10. Subjects understood and agreed to sign the informed consent form.

Exclusion Criteria:

• 1. Contraindications of Peginterferon such as depressive disorder, epilepsy, autoimmune diseases, uncontrolled thyroid dysfunction, etc

     2. Subjects with cirrhosis, e.g., definite cirrhosis on imaging such as abdominal ultrasound and CT; liver biopsy with Metavir fibrosis score = 4; clinical diagnosis of cirrhosis by the investigator.
     3. Decompensated liver disease
     4. Child-Pugh score of B-C or over 6 points.
     5. Subjects with any of the following circumstances
• History of decompensated liver disease
• History of serious heart disease (including unstable or uncontrolled heart disease within 6 months)
• Uncontrolled seizures, severe psychiatric disorders, or a history of psychiatric disorders
• with history of organ transplantation
• with poorly controlled diabetes and hypertension
• with autoimmune diseases, immune-related extrahepatic manifestations, thyroid disease, malignant tumors, or in immunosuppressive therapy
• underlying diseases such as malignant tumor, severe infection, heart failure and chronic obstructive pulmonary disease and other serious diseases.

• with history of alcohol or drug abuse

  6. Creatinine clearance \<60 mL/min.
  7. HAV, HCV, HDV, HEV or HIV co-infection
  8. Subjects who must be treated with Nucleosides (acids) other than TAF during treatment period
  9. Subjects who used interferon in the 6 months prior to the screening period
  10. Positive for anti-HBV Pre-S1 antibody.
  11. Hemocytopenia: White blood cells \< 3 × 10\^9 / L, neutrophil \< 1.5 × 10\^9 / L, platelet \< 60 × 10\^9 / L,
  12. Female subjects pregnancy test positive
  13. known to be allergic to the investigational drug or the underlying treatment drug
  14. Other laboratories or auxiliary examinations are obviously abnormal