An observational study in Sepsis, Prognosis and Liver Injury, sponsored by Xijing Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-01-31.
Sponsored by Xijing Hospital · Observational
Sepsis is a clinical syndrome with high morbidity and high fatality rate in emergency department. Patients with acute liver or kidney injury are more likely to develop Multiple Organ Dysfunction Syndrome(MODS) secondary to the non-hepatic injury group, and the prognosis deteriorates significantly. At present, there is no unified diagnostic criteria for acute liver injury associated with sepsis, and the commonly used prognostic evaluation system is rarely included in liver injury indicators, which is not good for practicality.
The project intends to collect the peripheral blood of the normal population, 24 hours after the onset of sepsis and patients in the recovery period. We will separate and extract plasma, Peripheral Blood Mononuclear Cell(PBMC), and plasma exosomal miRNA, and sequence to find indicators related to disease deterioration and prognosis. And then, we will construct and verify the early warning and prognosis evaluation system.
On this basis, the researcher explore cellular and molecular mediated pathological mechanisms of sepsis, and then clarify the treatment target of sepsis.
1,899 studies on the registry are indexed under Sepsis; 458 are open to participants now.
This study's planned enrollment of 300 is above the median of 160 across 929 observational studies indexed under Sepsis.
Browse Sepsis studies →Xijing Hospital is the lead sponsor of 465 studies on the registry; 157 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Healthy volunteers
Diagnostic Test: Peripheral blood test
Patients within 24 hours after onset
Diagnostic Test: Peripheral blood test
Inflammation was controlled, shock was corrected, and the patient remained fever free for 3 consecutive days.
Diagnostic Test: Peripheral blood test
Collect peripheral blood to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to find indicators related to disease deterioration and prognosis
Rate of Surviving or Died Participants with sepsis
Prognosis
Time frame: Day 30
Rate of Surviving or Died Participants with sepsis
Prognosis
Time frame: Day 90
Sepsis-associated liver injury
Concentration of Alanine aminotransferase(ALT) \>80 U/L or Glutamine oxaloacetic transaminase (GOT,AST) \>80 U/L, Concentration of total bilirubin(TBIL)\>2mg/dl（34μmol/l）
Time frame: Day 0
Sepsis-associated kidney injury
Concentration of Creatinine(Cr)\>2 mg/dl or Urine output \< 500ml/Day
Time frame: Day 0
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Nov 2022. You cannot join it, but the record below documents what was studied.
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Xijing Hospital