CompletedNCT05220371Updated Aug 28, 2023

Influence of Specific Collagen Peptides on Recovery After Exercise Induced Muscle Damage

An interventional study of Collagen and Concurrent training in Recovery, sponsored by University of Vienna. Completed at 1 site in Austria. Open to male participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-08-28.

Sponsored by University of Vienna · Not applicable, Interventional, and Basic science

Phase: Not applicable
Study type: Interventional
Enrollment: 50
Allocation: Randomized
Ages: 18 Years to 40 Years
Sex: Male

Study summary

The present study aims at investigating the potential influence of specific collagen peptides on recovery after exercise induced muscle damage with focus on long-term effects.

Conditions studied

Recovery

Keywords

Collagen peptides
Concurrent training
Ultrasound
MVC
RFD

In context

Lead sponsor

University of Vienna is the lead sponsor of 49 studies on the registry; 16 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years to 40 Years
Sexes eligible: Male
Accepts healthy volunteers: Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

No subjective symptoms during physical exertion
Stable weight and dietary behaviour
Body Mass Index (BMI) between 18.5 and 24.9
No extensive strength/endurance sports so far (less than 3 h/week)
No complaints during strenuous physical activity

Exclusion criteria

Exclusion Criteria:

Circumstances that impair/prevent sporting activity (e.g. chronic heart disease, arrhythmia, heart valve disease, arthritis etc.)
Intolerance/aversion to animal protein
Arterial hypertension (high blood pressure) (syst > 200 mmHg and/or diast > 105 mmHg) at rest
Presence of insulin-dependent diabetes mellitus
Liver and/or kidney disease that precludes a high protein load
Collagen supplementation or regular intake of other dietary supplements in the last 6 months.

Study design

Phase: Not applicable
Primary purpose: Basic science
Allocation: Randomized
Intervention model: Parallel assignment
Masking: Double (Participant, Investigator)
Enrollment: 50 participants (actual)

Study arms

Experimental
Collagen
15g of collagen peptides ingested daily
Dietary Supplement: Collagen · Other: Concurrent training
Placebo comparator
Placebo
15g of Placebo ingested daily
Other: Concurrent training

Interventions

Dietary supplementCollagen
Participants ingest 15 grams of either specific collagen peptides or Placebo daily
OtherConcurrent training
Both arms undergo a 12-week trainingintervention 3x/week

What researchers measure

Primary outcomes

Change in maximal voluntary contraction (MVC)
Measured by isokinetic dynamometer
Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in rate of force development (RFD)
Measured by isokinetic dynamometer
Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in countermovement jump height (CMJ)
Measured by force plate
Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in subjective pain score
Measured by visual analogue scale
Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in Achilles tendon cross-sectional area
Measured by ultrasound
Time frame: Baseline and after 12 weeks
Change in Vastus Lateralis fibre length
Measured by ultrasound
Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in collagen related blood markers
Measured by blood analysis
Time frame: Baseline (pre, post, 2 hours, 24 hours, 48 hours) and after 12 weeks (pre, post, 2 hours, 24 hours, 48 hours)
Change in Achilles tendon echo intensity
Measured by ultrasound
Time frame: Baseline and after 12 weeks
Change in Vastus Lateralis echo intensity
Measured by ultrasound
Time frame: Baseline and after 12 weeks
Change in body composition parameters (fat mass, fat-free mass, extracellular mass, body cell mass)
Measured by bioelectrical impedance analysis
Time frame: Baseline and after 12 weeks

Study locations

1 site

University of Vienna, Institute of Sport Science
Vienna, 1150, Austria

References and documents

Publications

Bischof K, Stafilidis S, Bundschuh L, Oesser S, Baca A, Konig D. Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides - a randomized controlled trial. Front Nutr. 2024 Mar 25;11:1384112. doi: 10.3389/fnut.2024.1384112. eCollection 2024. PubMed 38590831 ↗
Bischof K, Stafilidis S, Bundschuh L, Oesser S, Baca A, Konig D. Influence of specific collagen peptides and 12-week concurrent training on recovery-related biomechanical characteristics following exercise-induced muscle damage-A randomized controlled trial. Front Nutr. 2023 Nov 16;10:1266056. doi: 10.3389/fnut.2023.1266056. eCollection 2023. PubMed 38035363 ↗

Individual participant data

Plan to share: No

Timeline

Tracking since Sep 25, 2026

ElapsedEstimatedEstimated, not yet reached

Ran from Jan 2022 to primary completion in Jun 2023, 17 months.

How these figures are worked out, and which studies are left out of them.

Registered: Jan 28, 2022
First posted: Feb 2, 2022
StartActual: Jan 28, 2022
Primary completionActual: Jun 30, 2023
CompletionActual: Jun 30, 2023
Last update: Aug 28, 2023

What these dates mean

Start.: When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.: When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.: When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.: Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.

No changes since tracking began. The registry record was last updated on Aug 28, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT05220371
Lead sponsor: University of Vienna
Collaborators: Collagen Research Institute
Responsible party: Daniel König (Univ.-Prof. Dr. med. Daniel König, University of Vienna) — Principal investigator
First posted: Feb 2, 2022
Start date: Jan 28, 2022
Primary completion: Jun 30, 2023
Completion: Jun 30, 2023
Last update: Aug 28, 2023

Study contacts

Daniel Koenig, Prof. Dr.

principal investigator · University of Vienna, Institute of Sport Science

Oversight

Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2023. You cannot join it, but the record below documents what was studied.

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Discussion

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Studies of the drug tested here: Collagen

Other studies from this sponsor

University of Vienna

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