An observational study in Head and Neck Neoplasms and Radiation Therapy Complication, sponsored by University of Sydney. Completed at 1 site in Australia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-19.
Sponsored by University of Sydney · Observational
The primary objective of this observational study is to quantify the translation, rotation, and deformation of patient head positions of head and neck cancer patients over the course of a radiation therapy treatment for head and neck cancer. This objective will be achieved by comparing X-ray images collected during each treatment session with those obtained from the planning CT scan. Secondary objectives include (1) the use of the collected X-ray images to develop realistic artificial X-ray images where patient movement can be simulated and (2) to determine whether motion can be detected from individual X-ray images acquired during radiation therapy treatment.
Participants will undergo their radiation therapy treatment for HNC as planned and per the routine clinical management protocol. As part of this routine treatment, multiple x-ray images will be acquired to assist in accurate positioning of the patient for their planned radiation therapy. Normally these images are stored for a few days and then discarded. This study will be collating, storing and analysing these images. These X-ray images will be paired with the corresponding pre-treatment CT scan that is routinely acquired for each patient, as well as the locations of organs of interest, such as the tumour and surrounding structures. The patient treatment plan will also be collated, as it will allow for analysis of how any motion affects the accuracy of dose delivery. The patient radiation treatment delivery record will be collected to help sort and categorise the acquired images. Information on potential confounding or interacting factors will be collected: demographic information will be collected including sex, age, tumour stage and histology.
2,344 studies on the registry are indexed under Head and Neck Neoplasms; 551 are open to participants now.
This study's enrollment of 32 is below the median of 100 across 441 observational studies indexed under Head and Neck Neoplasms.
Browse Head and Neck Neoplasms studies →University of Sydney is the lead sponsor of 91 studies on the registry; 25 are open to participants now.
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Participants undergoing radiation therapy at Blacktown Hospital for head and neck cancer using a thermoplastic immobilisation mask
Exclusion Criteria:
Translational head motion between different radiation therapy treatment sessions
Translation error (mm)
Time frame: 8 weeks
Rotational head motion between different radiation therapy treatment sessions
Rotation error (degree)
Time frame: 8 weeks
Head deformation between different radiation therapy treatment sessions
Deformation error (mm)
Time frame: 8 weeks
Difference in structural similarity (SSIM) indexes between artificial and real X-rays
Image quality metric: Structural Similarity (SSIM) index.
Time frame: 8 weeks
Difference in mean absolute error between artificial and real X-rays
Image quality metric: Mean Absolute Error.
Time frame: 8 weeks
Plan to share: Yes — After study completion and publication, de-identified (non-coded, non-reidentifiable) data and medical images may be shared publicly with researchers for further scientific research. This will ensure that the potential of the data acquired in this trial is maximised. This is in accordance with the NHMRC guidelines on the publication and dissemination of research, and in line with archives, e.g. the TCIA (https://www.cancerimagingarchive.net/).
Supporting information: Study protocol, Sap, Icf, Csr, Analytic code
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This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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University of Sydney