An observational study in Myocardial Injury and Trigeminal Cardiac Reflex, sponsored by Beijing Tiantan Hospital. Completed at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-02-14.
Sponsored by Beijing Tiantan Hospital · Observational
Myocardial injury after noncardiac surgery is significantly related to postoperative 30-day mortality. Trigeminal cardiac reflex is one of the main causes of perioperative cardiac emergency. Therefore, the investigators' aim is to test the hypothesis that trigeminal cardiac reflex associates postoperative myocardial damage in participants undergoing skull base tumor surgery. The investigators will observe the association between trigeminal cardiac reflex and myocardial injury by measuring the concentration of plasma high sensitivity cardiac troponin (hs-cTnT) in participants after skull base tumor surgery.
98 studies on the registry are indexed under Neuroma, Acoustic; 27 are open to participants now.
This study's enrollment of 476 is above the median of 80 across 24 observational studies indexed under Neuroma, Acoustic.
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Patients aged more than 18 years old with American Society of Anesthesiology status I to III who will be scheduled to receive elective skull base tumor surgery under general anesthesia. Patients with trigeminal cardiac reflex during surgery will be included in the exposure group while patients without trigeminal cardiac reflex during surgery will be included in the non-exposure group.
Exclusion Criteria:
Other: Trigeminal cardiac reflex
Other: Non-trigeminal cardiac reflex
Trigeminal cardiac reflex occurred during the cerebellopontine angle tumor surgery.
No trigeminal cardiac reflex occurred during the cerebellopontine angle tumor surgery.
The incidence of postoperative myocardial injury
the elevation of plasma high sensitivity cardiac troponin I (hs-cTnI) caused by myocardial ischemia or injury (exclude other causes such as sepsis, pulmonary embolism, atrial fibrillation, etc). The blood samples before and within 24 hours after operation will be collected and measured by Roche's fourth generation hs-cTnI. It is commonly defined as an elevation as any value above the 99th percentile upper reference limit for each specific troponin I assay
Time frame: Postoperative 1 day.
The duration time of trigeminal cardiac reflex during skull base tumor surgery.
The duration time of trigeminal cardiac reflex during skull base tumor surgery.
Time frame: The whole skull base tumor surgery procedure.
Plan to share: No
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This study is completed, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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Beijing Tiantan Hospital