A Phase 2 interventional study of intraperitoneal Magnesium sulfate and intravenous magnesium sulfate in Post Operative Pain, Acute, sponsored by Sohag University. Status unknown at 1 site in Egypt. Open to female participants aged 20 Years to 44 Years. Per ClinicalTrials.gov, last updated 2022-01-26.
Sponsored by Sohag University · Phase 2, Interventional, and Health services research
Postoperative pain after laparoscopy may be localized pain resulting from incision due to many (two or three) punctures (somatic pain) or due to manipulation of the intra-abdominal organs as ovaries, uterus, omentum, and intestine (visceral pain) or shoulder and back pain caused by retained CO2 in the peritoneal cavity with its irritation effect on the diaphragm.Patients will be divided into two groups:
Intraperitoneal (IP) group (20 patients):They will receive 100 ml normal saline infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline intraoperatively then intraperitoneal wash of 100 ml normal saline containing 30 mg/kg MgSO4 at the end of laparoscopy.
Intravenous (IV) group (20 patients):They will receive 100 ml normal saline containing MgSO4 30 mg/kg infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline containing MgSO4 (8mg/kg) intraoperatively then intraperitoneal wash using 100 ml normal saline at the end of laparoscopy
5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.
This study's planned enrollment of 44 is below the median of 75 across 4,344 interventional studies indexed under Pain, Postoperative.
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20-44 years old females, (ASA) class I-II
Exclusion Criteria:
They will receive 100 ml normal saline infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline intraoperatively then an intraperitoneal wash of 100 ml normal saline containing 30 mg/kg MgSO4 at the end of laparoscopy.
Drug: intraperitoneal Magnesium sulfate
They will receive 100 ml normal saline containing MgSO4 30 mg/kg infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline containing MgSO4 (8mg/kg) intraoperatively then intraperitoneal wash using 100 ml normal saline at the end of laparoscopy.
Drug: intravenous magnesium sulfate
Intraperitoneal (IP) group will receive 100 ml normal saline infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline intraoperatively then intraperitoneal wash of 100 ml normal saline containing 30 mg/kg MgSO4 at the end of laparoscopy.
Intravenous (IV) group will receive 100 ml normal saline containing MgSO4 30 mg/kg infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline containing MgSO4 (8mg/kg) intraoperatively then intraperitoneal wash using 100 ml normal saline at the end of laparoscopy.
Time for first dose of rescue analgesia
1st time to feel pain
Time frame: 8 hours
total analgesic doses
total (ketorolac) analgesic consumption
Time frame: 8 hours
post operative pain
The visual analog scale(0-10 with 0 is no pain and 10 is maximum intolerable pain)
Time frame: 8 hours
sedation
4 points sedation scale: 0= alert and conscious 1 =quietly awake 2= asleep but easily arousable 3= deep sleep
Time frame: 8 hours
adverse events
side effects
Time frame: 8 hours
serum mgso4 level
serum level of mgso4 at end of operation and after 2 hours
Time frame: 2 hours
This study is status unknown, as verified in Jan 2022. You cannot join it, but the record below documents what was studied.
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Sohag University