An observational study in Propofol Overdose of Undetermined Intent, sponsored by West China Hospital. Completed at 1 site in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2021-12-15.
Sponsored by West China Hospital · Observational
Propofol is one of the most commonly used anesthetics in the world. However, the dose-response of propofol was remarkable variety. Herein, this study aims to investigate the possible association of gene polymorphism and propofol susceptibility, and to research more precise infusion model of this drug.
Patients undergoing gastrointestinal endoscopy will be recruited. Anesthesia is induced with propofol via TCI at 1.5µg/ml, and increases 0.5µg/ml for every 3min until OAA/S score 0. During this period, OAA/S score will be evaluated every 1min until OAA/S score 0. At this moment, the blood concentration of propofol, the doses of propofol, the onset time and BIS are recorded, and blood sample for gene polymorphism detection were required.
139 studies on the registry are indexed under Drug Overdose; 24 are open to participants now.
This study's enrollment of 400 is above the median of 175 across 38 observational studies indexed under Drug Overdose.
Browse Drug Overdose studies →West China Hospital is the lead sponsor of 484 studies on the registry; 241 are open to participants now.
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patients who will undergo gastrointestinal endoscopy with propofol
Exclusion Criteria:
patients undergoing gastrointestinal endoscopy
Drug: Propofol
anesthesia induction is initiated with intravenous infusion propofol at 1.5µg/ml, and increased 0.5µg/ml every 3min until OAA/S score 0.
Also known as: Diprivan
gene polymorphism of propofol susceptibility
combination of the blood concentration of propofol (ng/ml) with the onset time(min) at OAA/S score of 0 to demonstrate propofol susceptibility, the gene polymorphism of propofol susceptibility will be detected with the blood sample of subjects.
Time frame: from anesthesia induction to the end of the gastrointestinal endoscopy
This study is completed, as verified in Dec 2021. You cannot join it, but the record below documents what was studied.
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West China Hospital