An interventional study of Blood sample for the determination of antihypertensives or their metabolites. and Questionnaire on sexual activity in Hypertension, sponsored by University Hospital, Toulouse. Recruiting at 1 site in France. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-01.
Sponsored by University Hospital, Toulouse · Not applicable, Interventional, and Health services research
Several studies describe the existence of an association between sexual dysfunction and high blood pressure (hypertension), most often characterized by a decrease in the number of orgasms and the existence of dyspareunia.
Hypertension is a contributing factor, and nonadherence to medication could amplify it.
There are several ways to assess adherence to treatment: the use of declarative questionnaires, a method not without criticism because it is subject to the subjectivity of the declaration by the patient; and drug dosages, a standard technique, although insufficiently disseminated due to the high cost and greater weight of the survey protocols. Drug non-compliance is multifactorial. In addition, it has been shown that having undesirable drug effects and / or being afraid of developing them is one of the major causes of non-compliance with antihypertensive treatments.
The investigators hypothesize that DS is significantly more common among hypertensive women treated with non-observers compared to hypertensive women treated with observers.
The main objective is to compare the prevalence of sexual dysfunction between a group of hypertensive women treated as observers and a group of hypertensive women treated as non-observers.
6,114 studies on the registry are indexed under Hypertension; 912 are open to participants now.
This study's planned enrollment of 348 is above the median of 100 across 4,575 interventional studies indexed under Hypertension.
Browse Hypertension studies →University Hospital, Toulouse is the lead sponsor of 807 studies on the registry; 209 are open to participants now.
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You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Biological: Blood sample for the determination of antihypertensives or their metabolites. · Behavioral: Questionnaire on sexual activity · Behavioral: Scale on hospital anxiety and depression · Behavioral: Morisky Questionaire
15 ml of Blood sample for the determination of antihypertensives or their metabolites
Questionnaire on sexual activity in women
Scale on hospital anxiety and depression to detect anxious and depressive symptoms (14 questions)
anti-hypertensive medication compliance questionnaire
Analyse of sexual dysfunction
Prevalence of sexual dysfunction defined by a score less than 26 on the Female Sexual Function Index scale : score less than 26 mean a sexual dysfunction
Time frame: 25 months
Percentage of patients with a good medication compliance by drug dosages and the Morisky questionnaire
Compare two methods of assessing drug compliance: drug dosages in the blood and the Morisky questionnaire; The score is rated on 8 points. A score of 8 is considered "good observant", a score between 6 and 7 "moderately observant patient" and a score strictly lower than 6 "poor observant".
Time frame: 25 months
Number of cases with sexual dysfunction in hypertensive women according to the antihypertensive pharmacological classes used
Estimate the prevalence of sexual dysfunction according to the antihypertensive pharmacological classes used (in the biologicale analysis)
Time frame: 25 months
Number of cases with sexual dysfunction in hypertensive women according to the number of antihypertensive treatments;
Estimate the prevalence of sexual dysfunction according to the number of antihypertensive treatments;
Time frame: 25 months
Plan to share: No
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