An interventional study of Transcranial Doppler in Liver Transplantation, Ultrasonography, Doppler, Transcranial and Complication, Postoperative, sponsored by Mansoura University. Status unknown at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-04-14.
Sponsored by Mansoura University · Not applicable, Interventional, and Screening
This is a prospective study that would investigate the transcranial doppler (TCD) changes during the living donor liver transplantation and the association between the TCD changes and the post-transplant neurological complications.
Objectives:
Participants \& Setting:
Intervention \& Measurements:
Sample size:
1,267 studies on the registry are indexed under Postoperative Complications; 299 are open to participants now.
This study's planned enrollment of 100 is below the median of 117 across 710 interventional studies indexed under Postoperative Complications.
Browse Postoperative Complications studies →Mansoura University is the lead sponsor of 1,114 studies on the registry; 185 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
All patients will be evaluated with TCD for prediction of the post-transplant neurological complications
Diagnostic Test: Transcranial Doppler
Transcranial Doppler-derived parameters; pulsatility index (PI), resistance index (RI), mean flow velocity (Vmean) will be recorded before induction of anesthesia (T1). After induction, TCD parameters, Hemodynamic variables including heart rate (HR), invasive mean arterial blood pressure (MAP), and central venous pressure (CVP) together with Arterial blood gases (ABG analysis with values of PH, PCO2, PO2, blood oxygen saturation SO2 and bicarbonate HCO3), end-tidal carbon dioxide (ETCO2) and body temperature will be recorded too. Just before skin incision (T2), at the end of anhepatic phase 5 minutes before reperfusion (T3), 5 minutes after reperfusion (T4) and at the end of surgery (T5). Postoperatively at ICU, TCD parameters, Hemodynamic variables, and ABG will be obtained 24 hours postoperative (T6) and at discharge from ICU (T7).
Also known as: TCD
Post-transplant Neurological Complication
incidence of Neurological Complication as a composite outcome (tremors, seizures, demyelination, posterior reversible encephalopathy syndrome, stroke)
Time frame: 28 days after transplantation
flow patterns throughout the transplant surgery and in the ICU
normal, hyperemic, low-flow, or vasospastic flow by TCD
Time frame: intraoperative and 7 days after transplantion
Plan to share: Yes — Data will be available with the corresponding author at reasonable request. The Data publishing with the manuscript will be discussed later.
Time frame: will be updated
Access criteria: will be updated
No publications or documents are linked to this record.
Started Nov 2021 (actual). Primary completion is estimated for Nov 2023, 24 months after the start.
Of 377 non-industry interventional studies with no phase under Postoperative Complications, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 42. This study's planned 24 months is above that.
Counting every sponsor, half of 381 studies reached it within 22 months; a quarter within 8 and three quarters within 42.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.
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