An interventional study of Continuous Positive Airway Pressure and Deep inspiratory breath hold in Lung Cancer and Left Sided Breast Cancer, sponsored by Case Comprehensive Cancer Center. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-02.
Sponsored by Case Comprehensive Cancer Center · Not applicable, Interventional, and Supportive care
Among 26 studies in Lung Neoplasms by Case Comprehensive Cancer Center — 1 open to participants now, 1 under way, none of them phase 3. Lung Neoplasms · Case Comprehensive Cancer Center.
Among the 26 studies in Lung Neoplasms by Case Comprehensive Cancer Center, this one is the 11th largest by enrollment of the 19 interventional ones that give a count, is the only one that started in 2022, is one of 3 with no phase, and was the 25th registered.
5,422 studies on the registry are indexed under Lung Neoplasms; 1,346 are open to participants now.
Browse Lung Neoplasms studies →1 of the 26 studies in Lung Neoplasms by Case Comprehensive Cancer Center is open now, in 1 country. Recruiting first, the newest first:
Case Comprehensive Cancer Center · Sites in United States
By country, each count listing its studies:
Of the 996 Lung Neoplasms studies recruiting now, 683 (69%) set no upper age limit and 142 (14%) stop at 75 or younger; 45 take children under 18; 142 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
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26 studies; the count open now beside each. This study's row is marked.
First in 1998; this study’s year is marked. 1 started in 2022.
This study's enrollment of 8 is below the median of 60 across 3,656 interventional studies indexed under Lung Neoplasms.
Median enrollment 13 across the 19 interventional studies, 0 across the 7 observational. Of the 20 that completed or were terminated, 4 (20%) have results posted.
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Case Comprehensive Cancer Center is the lead sponsor of 494 studies on the registry; 61 are open to participants now.
Of its 75 completed or terminated interventional studies of FDA-regulated products, 46 (61%) have results posted.
1 of the studies in Lung Neoplasms by Case Comprehensive Cancer Center that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07104630Case Comprehensive Cancer CenterPulmonary Rehabilitation in Advanced Lung Cancer Survivors | 2026-12 |
Among the 26 studies in Lung Neoplasms by Case Comprehensive Cancer Center, from their registry updates:
Nothing recorded among them since 2026-09-25.
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Data collection and assessment on patients with left-sided breast cancer or undergoing lung stereotactic body radiation therapy (SBRT) utilizing continuous positive airway pressure (CPAP) devices.
Lung stereotactic body radiation therapy (SBRT) has emerged as a definitive treatment for patients with early-stage lung cancers as well as for patients with limited metastases to the lung. One challenge with the treatment of the lung is the risk of pulmonary toxicity, particularly for early-stage lungs cancers that are inoperable (those receiving primary lung SBRT) or those with metastatic cancers receiving systemic therapy that may impact pulmonary function (those receiving lung SBRT for metastatic cancers).
Continuous positive airway pressure (CPAP) devices are commonly utilized for patients with obstructive sleep apnea. However, through the use of continuous pressure, lung volumes are increased. Preliminary data in patients undergoing breast radiation as well as lung radiation has demonstrated the safety and feasibility of such an approach, demonstrating increased lung volumes with decreases in heart dose6-8. Additional potential advantages of CPAP include increased ease of use for patients and the potential for cost savings as compared to traditional respiratory management techniques.
This prospective study is to allow for the collection and assessment of data on patients with left-sided breast cancer or undergoing lung SBRT utilizing CPAP. This will allow for the assessment of lung doses with and without CPAP as well as cardiac doses. No additional changes to our standard of care breast or lung radiation will occur. With respect to the safety profile, CPAP is commonly used with limited toxicity concerns. The potential benefit of CPAP has reduced lung and heart doses and, consequently, radiation-related toxicities.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Patients with left-sided breast cancers
Patients undergoing lung SBRT
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.
Metastases
Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will come in for their regularly scheduled radiation planning and treatment. Participants will undergo three scans (with and without DIBH (i.e., free-breathing), with CPAP). Participants will also use the CPAP device before the CT scan, for which they will be educated and trained.
Device: Continuous Positive Airway Pressure · Other: Deep inspiratory breath hold · Other: Free Breath
Participants will come in for their regularly scheduled radiation planning and treatment. Participants will undergo three scans (with and without DIBH (i.e., free-breathing), with CPAP). Participants will also use the CPAP device before the CT scan, for which they will be educated and trained.
Device: Continuous Positive Airway Pressure · Other: Deep inspiratory breath hold · Other: Free Breath
Use of CPAP device at the start of treatment planning.
Also known as: CPAP
Treatment during breath holds leads to longer treatment times for patients and radiation oncology departments
Also known as: DIBH
Regular breathing
Also known as: Without DIBH
Dosimetry comparison CPAP and free breathing.
The primary objective will be to assess changes in lung dosimetry V5 on the affected side when using CPAP compared to free breathing will be measured in percentages.
Time frame: At the time of Scan, " Day 1"
Dosimetry comparison CPAP and free breathing.
The primary objective will be to assess changes in lung dosimetry V20 on the affected side when using CPAP compared to free-breathing will be measured in percentages.
Time frame: At the time of Scan, " Day 1"
Dosimetry comparison CPAP and free breathing.
The primary objective will be to assess changes in lung dosimetry mean lung on the affected side when using CPAP compared to free-breathing will be measured in Grays.
Time frame: At the time of Scan, " Day 1"
Total Lung dosimetry
Total Lung dosimetry will be measured in Grays.
Time frame: At the time of Scan, " Day 1"
Cardiac dosimetry with CPAP as compared to free breathing
Cardiac dosimetry with CPAP as compared to free-breathing will be measured in Grays.
Time frame: At the time of Scan, " Day 1"
Measure breast/chest wall or lung tumor motion as well as organ at risk motion
Simulation scans will be performed with CPAP and free breathing. The breast/chest wall, and tumors (lung SBRT), as well as lung and heart, will be contoured on each scan. Using the CPAP scan as a reference, we will assess breast/chest wall motion, lung tumor motion, and organ at risk (ex. heart, abdominal organs) motion with free-breathing scans for each patient and analyze by treatment site (breast vs. lung SBRT).
Time frame: At the time of Scan, " Day 1"
Treatment time with CPAP treatments
Treatment time will be measured for each fraction
Time frame: At the time of Scan, " Day 1"
Confirm maintenance of inflation with CPAP using surface guidance
At the time of simulation, investigators will create a surface rendering with the patient using CPAP. Investigators will assess maintenance of inflation when using CPAP where all three dimensions will be measured during treatment by comparing the surface rendering obtained during simulation with CPAP to the surface during treatment with CPAP, assessing for the greatest changes over the course of each fraction.
Time frame: At the time of Scan, " Day 1"
Ran from Oct 2022 to primary completion in Jan 2026, 39 months.
Of 864 non-industry interventional studies with no phase under Lung Neoplasms, half reached primary completion within 35 months of starting (the median), counting those still running; a quarter within 16 and three quarters within 68. This study's 39 months is above that.
Counting every sponsor, half of 915 studies reached it within 34 months; a quarter within 15 and three quarters within 67.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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