An observational study in Pre-Eclampsia, Early Onset Preeclampsia and Oxidative Stress, sponsored by Hatice Akkaya. Completed at 1 site in Turkey. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2021-10-28.
Sponsored by Hatice Akkaya · Observational
Early-onset Preeclampsia (PE) is a pregnancy disorder which may present with adverse pregnancy outcomes. Nectin-4 is an adhesion molecule mainly expressed in placenta. This study aimed to evaluate the relationship between early onset Preeclampsia and serum Nectin 4 levels.
Preeclampsia is assumed as a two-stage disorder arising from defective trophoblast invasion and failure of spiral artery remodeling as the main step responsible for the pathogenesis. PE is classified according to the disease onset time as early-onset PE before 34 weeks and late-onset PE after 34 weeks. Late-onset PE is more commonly seen and accepted as a mild maternal reaction to pregnancy. In early-onset PE, unlike the late-onset, due to the improper placental invasion, the diffuse placental ischemia and the resulting oxidative stress begin at early gestation. Thus, the early-onset PE may result in severe disease leading to perinatal and maternal morbidity and mortality.
The nectins are calcium-independent immunoglobulin-like celladhesion molecules and have a pivotal role at cellular junctions, as well as physiological regulations(8). Placenta expressesfor types of nectins; nectin-1, nectin-2, nectin-3, and nectin-4. They are localized at tight junctions and gap junctions of syncitiotrophoblasts(9). Nectin-4 is a relatively novel member of nectin family which has been detected only in placenta and airway epithelium in healthy subjects.
Despite, there has been no study published yet to reveal the soluble nectin-4 levels in preeclampsia as well as in early onset disease. In this study, we aimed to investigate the serum nectin-4 levels in early-onset preeclampsia in comparison of the healthy pregnancies.
Comparison to the level of soluble nectin-4 in early-onset PE, compared to healthy pregnancies
Exclusion Criteria:
43 cases The groups were matched for gestational age and gravidity.
Diagnostic Test: serum marker levels
41 cases The groups were matched for gestational age and gravidity
Diagnostic Test: serum marker levels
two groups comparisons
serum nectin-4 levels
ng/ml
Time frame: 1 hour
BMI (body mass index)
kg/m2
Time frame: 5 minute
Tansion Arterial
mm Hg
Time frame: 5 minute
Plan to share: Yes — If needed
Supporting information: Study protocol, Sap, Icf, Csr, Analytic code
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Hatice Akkaya