An observational study in Pre-Eclampsia, Early Onset Preeclampsia and Oxidative Stress, sponsored by Hatice Akkaya. Completed at 1 site in Turkey. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2021-10-28.
Sponsored by Hatice Akkaya · Observational
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Among 50 studies in Pre-Eclampsia with a site in Turkey — 11 open to participants now, 11 under way, none of them phase 3. Pre-Eclampsia · Turkey.
Among the 50 studies in Pre-Eclampsia with a site in Turkey, this one is the 22nd largest by enrollment of the 31 observational ones that give a count, is one of 6 that started in 2020, is one of 31 observational ones, and was the 23rd registered.
917 studies on the registry are indexed under Pre-Eclampsia; 244 are open to participants now.
Browse Pre-Eclampsia studies →11 of the 50 studies in Pre-Eclampsia with a site in Turkey are open now. Recruiting first, the newest first:
Muğla Sıtkı Koçman University · Sites in Turkey
Ages 18–45 · Women only · Healthy volunteers
Istanbul University - Cerrahpasa · Sites in Turkey
Ages 18+ · Women only
Samsun University · Sites in Turkey
Ages 18–45 · Women only · Healthy volunteers
Aysegul Kilicli · Sites in Turkey
Ages 19–49 · Women only · Healthy volunteers
Umraniye Education and Research Hospital · Sites in Turkey
Ages 18–39 · Women only
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 162 Pre-Eclampsia studies recruiting now, 81 (50%) set no upper age limit and 80 (49%) stop at 75 or younger; 18 take children under 18; 60 take healthy volunteers.
This study: 18 Years to 40 Years · female · no healthy volunteers.
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50 studies; the count open now beside each. This study's row is marked.
First in 2008; this study’s year is marked. 6 started in 2020.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 84 is below the median of 165 across 397 observational studies indexed under Pre-Eclampsia.
Median enrollment 84 across the 19 interventional studies, 96 across the 31 observational. Of the 31 that completed or were terminated, 1 (3%) have results posted.
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None of the 50 has an industry lead sponsor. The 10 most frequent:
Hatice Akkaya is the lead sponsor of 3 studies on the registry; none are open to participants now.
Hatice Akkaya has 1 study filed under Pre-Eclampsia — fewer than ten, so there is no comparison to draw.
2 of the studies in Pre-Eclampsia with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07874191Muğla Sıtkı Koçman UniversityRetinal and Choroidal Microcirculation in Preeclampsia: An OCTA Study | 2026-12-29 |
| NCT07745036Samsun UniversityRole of Progesterone Membrane Receptors in the Pathogenesis of Preeclampsia | 2027-01-01 |
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Among the 50 studies in Pre-Eclampsia with a site in Turkey, from their registry updates:
This tab as a report to print or save as PDF → With an account.
Early-onset Preeclampsia (PE) is a pregnancy disorder which may present with adverse pregnancy outcomes. Nectin-4 is an adhesion molecule mainly expressed in placenta. This study aimed to evaluate the relationship between early onset Preeclampsia and serum Nectin 4 levels.
Preeclampsia is assumed as a two-stage disorder arising from defective trophoblast invasion and failure of spiral artery remodeling as the main step responsible for the pathogenesis. PE is classified according to the disease onset time as early-onset PE before 34 weeks and late-onset PE after 34 weeks. Late-onset PE is more commonly seen and accepted as a mild maternal reaction to pregnancy. In early-onset PE, unlike the late-onset, due to the improper placental invasion, the diffuse placental ischemia and the resulting oxidative stress begin at early gestation. Thus, the early-onset PE may result in severe disease leading to perinatal and maternal morbidity and mortality.
The nectins are calcium-independent immunoglobulin-like celladhesion molecules and have a pivotal role at cellular junctions, as well as physiological regulations(8). Placenta expressesfor types of nectins; nectin-1, nectin-2, nectin-3, and nectin-4. They are localized at tight junctions and gap junctions of syncitiotrophoblasts(9). Nectin-4 is a relatively novel member of nectin family which has been detected only in placenta and airway epithelium in healthy subjects.
Despite, there has been no study published yet to reveal the soluble nectin-4 levels in preeclampsia as well as in early onset disease. In this study, we aimed to investigate the serum nectin-4 levels in early-onset preeclampsia in comparison of the healthy pregnancies.
Comparison to the level of soluble nectin-4 in early-onset PE, compared to healthy pregnancies
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
43 cases The groups were matched for gestational age and gravidity.
Diagnostic Test: serum marker levels
41 cases The groups were matched for gestational age and gravidity
Diagnostic Test: serum marker levels
two groups comparisons
serum nectin-4 levels
ng/ml
Time frame: 1 hour
BMI (body mass index)
kg/m2
Time frame: 5 minute
Tansion Arterial
mm Hg
Time frame: 5 minute
Plan to share: Yes — If needed
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report, Analytic code
Time frame: 1 year
Access criteria: journals editors request
No publications or documents are linked to this record.
Ran from May 2020 to primary completion in Dec 2020, 7 months.
Of 191 non-industry observational studies under Pre-Eclampsia, half reached primary completion within 27 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 56. This study's 7 months is below that.
Counting every sponsor, half of 200 studies reached it within 30 months; a quarter within 11 and three quarters within 56.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Oct 2021. You cannot join it, but the record below documents what was studied.
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Hatice Akkaya