An observational study in Acute Ischemic Stroke, sponsored by The Affiliated Hospital of Xuzhou Medical University. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-08-06.
Sponsored by The Affiliated Hospital of Xuzhou Medical University · Observational
CRAST is to analyze the expression pattern of circular RNA (circRNA) by bioinformatics analysis in patients with acute ischemic stroke and healthy control. The candidate circRNA will be verified as biomarkers for the detection and prognosis of acute ischemic stroke.
Circular RNAs have been highlighted to be involved in the pathological process of ischemic stroke (IS). The purpose of this protocol will investigate the expression pattern of circular RNA (circRNA) by bioinformatics analysis in patients with acute ischemic stroke and healthy control. The candidate circRNA will be verified as biomarkers for the detection and prognosis of acute ischemic stroke. Distinctive expression patterns of circRNA will be identified by individual quantitative real time polymerase chain reaction (qRT-PCR). A diagnostic or predictive model will be established using logistic regression. The panel of these altered circRNAs may be associated with acute IS and could serve as a novel diagnostic or predictive method.
7,283 studies on the registry are indexed under Stroke; 2,013 are open to participants now.
This study's planned enrollment of 500 is above the median of 160 across 1,692 observational studies indexed under Stroke.
Browse Stroke studies →The Affiliated Hospital of Xuzhou Medical University is the lead sponsor of 66 studies on the registry; 31 are open to participants now.
Counted across the registry records on this site, refreshed daily.
There will be 100 patients suspected of AIS (such as transient ischemic attack), 300 AIS patients and 100 Healthy controls，whose data will be applied for construction and validation of diagnostic and predictive models of circRNA from the circulating blood.
Exclusion Criteria:
This group includes patients with acute ischemic stroke (AIS).
Genetic: Quantitative Real-time polymerase chain reaction
This group includes healthy controls (HC).
Genetic: Quantitative Real-time polymerase chain reaction
Quantitative Real-time polymerase chain reaction of circular RNA (circRNA).
Differential expression pattern of circRNA
Differential expression pattern of circular RNA (circRNA) will be compared between AIS group and HC group, thus candidate circRNA will be verified as biomarkers for the detection and prognosis of AIS.
Time frame: 90 days
Dynamic changes of circRNA during the follow-up period
Dynamic changes of circRNA will be explored before and after endovascular therapy
Time frame: 90 days
Correlation of circRNA and stroke-associated infection
Correlation of circRNA and stroke-associated infection will be explored in acute ischemic stroke.
Time frame: 30 days
Correlation of circRNA and inflammatory factors in acute ischemic stroke
Correlation of circRNA and inflammatory factors on admission will be explored in acute ischemic stroke.
Time frame: 7 days
Prognostic value of circRNA in acute ischemic stroke
The prognosis of AIS patients will be analyzed between differential expressed candidate circRNA after they have completed the systematic therapy.
Time frame: 90 days
Plan to share: No
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The Affiliated Hospital of Xuzhou Medical University