An interventional study of transcranial magnetic stimulation and sham stimulation in Schizophrenia, sponsored by Central South University. Status unknown at 1 site in China. Open to participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2022-11-17.
Sponsored by Central South University · Not applicable, Interventional, and Treatment
cTBS is a promising novel intervention, which have strong potentials on moderating disease syndrome, suck as verbal hallucination, and cognitive deficits in schizophrenia, as it has been proved for the treatment of depression.
Therefore, the investigators designed this randomized controlled clinical trial to evaluate the efficacy and safety of cTBS on prevention and treatment for cognitive deficiency, psychotic syndrome and metabolic side-effects in drug-naive first episode individual with schizophrenia.
cTBS is a promising novel intervention, which have strong potentials on moderating disease syndrome, suck as verbal hallucination, and cognitive deficits in schizophrenia, as it has been proved for the treatment of depression.
Therefore, the investigators designed this randomized controlled clinical trial to evaluate the efficacy and safety of cTBS on prevention and treatment for cognitive deficiency, psychotic syndrome and metabolic side-effects in drug-naive first episode individual with schizophrenia.
3,471 studies on the registry are indexed under Schizophrenia; 472 are open to participants now.
This study's enrollment of 44 is below the median of 70 across 2,872 interventional studies indexed under Schizophrenia.
Browse Schizophrenia studies →Central South University is the lead sponsor of 126 studies on the registry; 29 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
The participants randomized into experimental group will receive cTBS stimulation of left M1 area for 5 times a day, with 1h interval between two stimulations, and for 5 continuous days.
Device: transcranial magnetic stimulation
The participants randomized into experimental group will receive sham stimulation of left M1 area for 5 times a day, with 1h interval between two stimulations, and for 5 continuous days.
Device: sham stimulation
transcranial magnetic stimulation with continuous theta burst pattern, 90% RMT, 50Hz within train and 5Hz train for 200 train and 40 second in total.
TMS coil vertical to the brain surface, with same protocol as cTBS
Three-Factor Eating Questionnaire
min value 21, max value 84. The higher scores mean more unhealthy eating behavior.
Time frame: Change from Baseline to 6days and 36days
MCCB
The MATRICS™ Consensus Cognitive Battery
Time frame: Change from Baseline to 6days and 36days
The positive and negative syndrome scale
min score 30, max score 210. The higher score means more severe symptoms.
Time frame: Change from Baseline to 6days and 36days
BMI
body mass index
Time frame: Change from Baseline to 6days and 36days
Resting EEG
resting EEG (electroencephalogram) with eyes opened, eye closed and natural stimulation. The reEEG power spectra, functional connection will be calculated.
Time frame: Change from Baseline to 6days and 36days
fasting glucose
in mmol/l
Time frame: Change from Baseline to 6days and 36days
Triglyceride
in mmol/l
Time frame: Change from Baseline to 6days and 36days
Total Cholesterol
in mmol/l
Time frame: Change from Baseline to 6days and 36days
Low Density Lipoprotein
in mmol/l
Time frame: Change from Baseline to 6days and 36days
High Density Lipoprotein
in mmol/l
Time frame: Change from Baseline to 6days and 36days
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Nov 2022. You cannot join it, but the record below documents what was studied.
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Central South University