An observational study in Hip Fracture (First Incidence of), sponsored by University of Leeds. Completed at 1 site in United Kingdom. Open to female participants aged 36 Years to 69 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-09-23.
Sponsored by University of Leeds · Observational
Hip fracture is a common serious injury in older women that reduces quality of life and can lead to premature death. In the United Kingdom, hip fractures are estimated to account for 1.5 million hospital bed days used per year due to long hospitalisation and rehabilitation periods post-surgery, costing the National Health Service over £1 billion per year. Diet can affect bone health and risk of hip fracture, with varying risks in women on specific diets, and specific foods and nutrients playing more important roles than others. Vegetarians may be at a greater risk of hip fracture than meat-eaters, and those who don't consume enough protein could be at a greater risk than those with adequate intakes. This research aims to investigate which dietary factors (and in what quantities) might predispose United Kingdom women to a greater risk of hip fracture, and which factors may be protective. The purpose of this study is to better understand the role of diet in reducing hip fracture risk in United Kingdom women. The research will use existing dietary and lifestyle data from the United Kingdom Women's Cohort Study and hospital records of hip fractures.
Background: Hip fracture is an increasingly prevalent global health condition that increases morbidity and mortality. Previous observational studies have shown potential for risk reduction through diet modification, but associations between many dietary factors and hip fracture incidence are uncertain, and evidence in United Kingdom populations is limited. Therefore, this study aims to assess associations between diet and hip fracture incidence in the United Kingdom Women's Cohort.
Research plan and methods: The investigators will utilise dietary and lifestyle data from the United Kingdom Women's Cohort which recruited 35,372 middle-aged women between 1995-1998. This data has been linked with Hospital Episode Statistics to provide hip fracture data of participants.
Cox regression models will be applied to explore potential associations between dietary factors and hip fracture incidence. Dietary factors will be modelled both as categorical and continuous so that models can be fit comparing the risk of hip fracture between categories of intakes and per increment increase in exposure intake (linear dose-response). Cubic splines will be used to model non-linear associations for dietary intake of fruits, vegetables, tea, and coffee since previous research has suggested possible non-linear associations for these variables.
2,261 studies on the registry are indexed under Fractures, Bone; 325 are open to participants now.
This study's enrollment of 35,372 is above the median of 100 across 675 observational studies indexed under Fractures, Bone.
Browse Fractures, Bone studies →University of Leeds is the lead sponsor of 200 studies on the registry; 25 are open to participants now.
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The UK Women's cohort profile is published here: [https://doi.org/10.1093/ije/dyv173].
Exclusion Criteria:
United Kingdom Women's Cohort Study. No interventions are to be administered in this observational prospective cohort study.
Other: Dietary pattern · Other: Fruit and vegetable intake · Other: Meat intake · Other: Fish intake · Other: Egg intake · Other: Dairy intake · Other: Tea intake · Other: Coffee intake · Other: Tea and coffee intake · Other: Protein intake · Other: Calcium intake · Other: Vitamin D intake
(regular meat-eater, occasional meat-eater, fish-eater, vegetarian, and vegan)
Intake of fruits, vegetables, fruits and vegetables combined from food frequency questionnaire
Red meat, poultry, processed meat from food frequency questionnaire
Intake of fish from food frequency questionnaire
Intake of eggs from food frequency questionnaire
Intake of dairy products from food frequency questionnaire
Intake of tea (drink) from food frequency questionnaire
Intake of coffee (caffeinated or decaffeinated) from food frequency questionnaire
Combined intake of tea and coffee from food frequency questionnaire
Estimated intake of protein, derived from food frequency questionnaire
Estimated intake of calcium, derived from food frequency questionnaire
Estimated intake of vitamin D, derived from food frequency questionnaire and any recorded supplemental intake
Hip fracture incidence (first)
Incidence of first hip fracture ascertained from linkage to Hospital Episode Statistics (HES) data
Time frame: age when the completed questionnaire was returned (1995-1998) until age at event, death, or end of study period (19 Mar 2019)
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Plan to share: No
This study is completed, as verified in Sep 2022. You cannot join it, but the record below documents what was studied.
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University of Leeds