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CompletedNCT05028491Updated Sep 8, 2021

The Influence of Meibomian Gland Expression on Corneal Aberrations in MGD Patients

An observational study in Meibomian Gland Dysfunction, sponsored by Wenzhou Medical University. Completed at 1 site in China. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2021-09-08.

Sponsored by Wenzhou Medical University · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
62
Ages
18 Years to 90 Years
Sex
All
01

Study summary

To evaluate the influence of corneal-aberrations before and after the meibomian gland thermal massage treatment.

Read the detailed description

62 MGD patients treated with meibomian gland thermal massage once a week for 3 to 4 weeks were recruited.The Ocular Surface Disease Index questionnaire; tear film assessment encompassing tear meniscus height and non-invasive keratograph breakup time ; meibography score,corneal fluorescein staining; the Schirmer I test ; expressible meibomian gland, and quality ,anterior and total corneal aberrations were evaluated before and after treatment.

02

Conditions studied

  • Meibomian Gland Dysfunction

Keywords

  • thermal massage
  • corneal aberrations
  • physical therapy
03

In context

Meibomian Gland Dysfunction

168 studies on the registry are indexed under Meibomian Gland Dysfunction; 21 are open to participants now.

This study's enrollment of 62 is below the median of 80 across 21 observational studies indexed under Meibomian Gland Dysfunction.

Browse Meibomian Gland Dysfunction studies →

Lead sponsor

Wenzhou Medical University is the lead sponsor of 93 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Diagnosed as meibomian glands dysfunction in our hospital; treatment with thermal massage and expression

Inclusion criteria

  • tear break-up time (BUT) ≤10 seconds or Schirmer I test (SIT) ≤10 mm, the presence of dry eye symptoms, and fluorescein staining (FL) score \<3 points and at least one lid margin abnormality and poor meibomian gland expressibility

Exclusion criteria

Exclusion Criteria:

  • eyelid structure abnormal(Entropion , ectropion);
  • having received any other treatment for MGD within three months
  • history of ocular surgery
  • contact lens use
  • ocular infection
  • any type of corneal scarring
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
62 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. corneal aberration corneal aberrations

    Corneal aberrations were measured with a Pentacam。 The anterior corneal wavefront aberration was expanded with normalized Zernike polynomials.The corneal aberration from 3rd to 6th order were recorded as the root mean square (RMS) for analysis.

    Time frame: baseline and 1 week after treatment

07

Study locations

1 site
  • Eye Hospital of Wenzhou Medical College
    Wenzhou, Zhejiang 325027, China
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 8, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT05028491
Lead sponsor
Wenzhou Medical University
Responsible party
Yune Zhao (Vice president of Eye Hospital of Wenzhou Medical University, Wenzhou Medical University) — Principal investigator
First posted
Aug 31, 2021
Start date
Oct 1, 2020
Primary completion
Jun 29, 2021
Completion
Jul 29, 2021
Last update
Sep 8, 2021

Study contacts

Yune Zhao
study director · Ophthalmology and Optometry Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2021. You cannot join it, but the record below documents what was studied.

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