An interventional study of edaravone dexborneol or edaravone in Acute Ischemic Stroke, sponsored by Lili Cao. Status unknown at 1 site in China. Open to participants aged 50 Years to 80 Years. Per ClinicalTrials.gov, last updated 2021-09-13.
Sponsored by Lili Cao · Not applicable, Interventional, and Treatment
The patients of acute ischemic stroke were divided into two groups, edaravone dexborneol treatment group and edaravone treatment group. The purpose of this study was to observe the changes of imaging and the improvement of NIHSS and mRS in different groups.
A total of 80 patients with acute ischemic stroke of middle cerebral artery were randomly divided into two groups, edaravone dexborneol treatment group and edaravone treatment group. The mismatch area between the low perfusion area of MRI 3D-ASL and the infarct area of DWI was defined as the ischemic penumbra, and the CBF perfusion pseudo color images with PLD of 1.5s and 2.5s were recorded. The above two CBF perfusion images were subtracted, and the residual area was quantitatively analyzed to reflect the establishment of collateral circulation. We aimed to observe whether there were differences in the improvement of ischemic penumbra and the establishment of collateral circulation between two groups after treatment. Besides, the improvment of NIHSS and mRS was also observed in different periods.
2,593 studies on the registry are indexed under Ischemic Stroke; 931 are open to participants now.
This study's planned enrollment of 80 is below the median of 120 across 1,752 interventional studies indexed under Ischemic Stroke.
Browse Ischemic Stroke studies →Lili Cao is the lead sponsor of 4 studies on the registry; 1 is open to participants now.
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Drug: edaravone dexborneol or edaravone
Drug: edaravone dexborneol or edaravone
Edaravone dexborneol or edaravone is going to be used in two different groups to compare the efficacy.
image changes in different groups
Time frame: 7 days
NIHSS changes in different groups
Time frame: 7days，14 days, 90 days
mRS changes in different groups
Time frame: 7days，14 days, 90 days
Plan to share: No
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This study is status unknown, as verified in Sep 2021. You cannot join it, but the record below documents what was studied.
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Lili Cao