An interventional study of multi-modal targeted intervention (e.g., cognitive training, exercise, games) in Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD) and Aging, sponsored by National Research Center for Rehabilitation Technical Aids. Recruiting at 1 site in China. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-05-22.
Sponsored by National Research Center for Rehabilitation Technical Aids · Not applicable, Interventional, and Screening
This study investigates the neural mechanisms of cognitive function decline, cognitive assessment methods for subjects with mild cognitive dysfunction (Mild cognitive impairment, MCI, or cognitive decline milder than MCI), and the approaches used to improve and restore cognitive function.
Cognitive assessment tools are used to assess cognitive function of subjects in different cities. Functional and structural MRI and EEG are applied to investigate the neural mechanisms of cognitive function decline and effects of methods to improve and restore cognitive function.
3,845 studies on the registry are indexed under Cognitive Dysfunction; 1,100 are open to participants now.
This study's planned enrollment of 100 is above the median of 64 across 2,810 interventional studies indexed under Cognitive Dysfunction.
Browse Cognitive Dysfunction studies →National Research Center for Rehabilitation Technical Aids is the lead sponsor of 6 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Control group, without specific treatments
This group receives treatments to improve cognitive function.
Combination Product: multi-modal targeted intervention (e.g., cognitive training, exercise, games)
The Intervention group will be given recommended interventions tailored to individuals based on their risks (e.g., physical exercise programs, cognitive training, dietary advice, control of blood pressure and cholesterol, healthy diet, control obesity, stop smoking,reduce alcohol excess)
Change in Cognitive function (SCD-9)
The SCD-9 questionnaire is used to assess cognitive function of participants.
Time frame: Change from Baseline Cognitive test results at 3 months.
Change in Cognitive function (MoCA)
The Montreal Cognitive Assessment test is used to assess cognitive function of participants.
Time frame: Change from Baseline Cognitive test results at 3 months.
Change in Cognitive function (AD8)
The AD8 test is used to assess cognitive function of participants.
Time frame: Change from Baseline Cognitive test results at 3 months.
Change in Cognitive function (CDR)
The Clinical Dementia Rating (CDR) test is used to assess cognitive function of participants.
Time frame: Change from Baseline Cognitive test results at 3 months.
Change in Physical capacity (TUG)
The timed up and go (TUG) test is used to evaluate physical capacity of participants.
Time frame: Change from Baseline physical capacity test results at 3 months.
Change in Physical capacity (chair standing)
The 30-second chair standing test is used to evaluate physical capacity of participants.
Time frame: Change from Baseline physical capacity test results at 3 months.
Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
Number of participants with treatment-related adverse events as assessed by CTCAE v5.0.
Time frame: Up to 24 months.
Plan to share: No
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National Research Center for Rehabilitation Technical Aids