An interventional study of New Zealand blackcurrants (NZBC) and Placebo (PLA) in Muscle Damage, sponsored by University of Surrey. Completed at 1 site in United Kingdom. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-08-18.
Sponsored by University of Surrey · Not applicable, Interventional, and Prevention
The study aims to examine the effect of a New Zealand blackcurrant (NZBC) supplement on markers of muscle damage and recovery following strenuous resistance exercise. The investigation will compare responses between an experimental (NZBC capsule, 300 mg/day) and placebo (PLA capsule, 300 mg sugar) group. Participants will attend a screening session where they will consent to the study, complete a pre-activity medical questionnaire and have their height, weight and resting blood pressure measured. If the participants meet the inclusion criteria they will perform a familarisation session on the muscle strength assessment. Participants will be randomized to NZBC or placebo groups, and consume one capsule in the morning (between 6-10 am) for 12 days. This is a double-blinded study, which means that the participant and the study team will not know which group the participants are assigned to until the study is over. On day 8 participants will perform a strenuous bout of upper body resistance exercise on the isokinetic dynamometer (exercise device). Muscle strength and soreness, arm circumference, and elbow range of motion will be measured, and a fasted blood sample will be collected, before and 24, 48, 72 \& 96 hours after the muscle fatigue protocol (on days 9, 10, 11 \& 12). A marker of muscle damage (creatine kinase [CK] concentration) will be measured in the blood samples. Participants will also be asked to complete a 6-day dietary record, beginning on day 7 and ending on the final day of testing (day 12).
University of Surrey is the lead sponsor of 90 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
1 NZBC capsule (containing 300 mg active cassis containing 105 mg of anthocyanins, i.e. 35-50 % delphinidin-3-rutinoside, 5-20 % delphinidin-3-glucoside, 30-45 % cyanidin-3-rutinoside, 3-10 % cyanidin-3-glucoside), consumed in the morning, for 12 days.
Dietary Supplement: New Zealand blackcurrants (NZBC)
1 placebo capsule (containing 300 mg microcrystalline cellulose M102), consumed in the morning, for 12 days.
Dietary Supplement: Placebo (PLA)
NZBC capsules containing anthocyanin-rich blackcurrant extract
Also known as: NZBC extract supplement (Health Currancy Ltd [UK] / CurraNZ Ltd [NZ])
Placebo capsules containing microcrystalline cellulose
Also known as: Placebo capsules
Change from baseline in creatine kinase (CK) concentration at 72 hours post-exercise
Serum biomarker for muscle damage
Time frame: At baseline (pre-exercise) and 72 hours post-exercise.
Change from baseline in creatine kinase (CK) concentration at 96 hours post-exercise
Serum biomarker for muscle damage
Time frame: At baseline (pre-exercise) and 96 hours post-exercise..
Change in maximum voluntary contraction (MVC) from baseline to 96 hours post-exercise
Muscle function measure; maximal voluntary isometric contraction (torque, Nm) performed on isokinetic dynamometer
Time frame: At baseline (pre-exercise) and post-exercise time points (at 0, 24, 48, 72 and 96 hours respectively).
Change in rating of Delayed Onset of Muscle Soreness (DOMS) from baseline to 96 hours post-exercise
Self-reported perception of muscle soreness using a visual analogue scale (VAS), from 'no soreness' \[0 mm\] on the left anchor point to 'extremely sore' \[100 mm\] on the right
Time frame: At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).
Change in joint range of motion (ROM) from baseline to 96 hours post-exercise
Elbow ROM measured using a goniometer
Time frame: At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).
Change in mid arm circumference (MAC) from baseline to 96 hours post-exercise
Mid-upper arm circumference measured at the midpoint of the distance from the acromion process (acromiale) to the olecranon process (radiale).
Time frame: At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).
Plan to share: No — Will provide basic data spreadsheet upon request.
No publications or documents are linked to this record.
This study is completed, as verified in Aug 2021. You cannot join it, but the record below documents what was studied.
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University of Surrey