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CompletedNCT04996290Updated Aug 9, 2021

Combined PENG and LFCN Block for Total Hip Arthroplasty

An interventional study of PENG + LFCN block and Ropivacaine injection in Anesthesia, Conduction, Pain, Postoperative and Arthroplasty, Replacement, Hip, sponsored by University Hospital, Antwerp. Completed at 1 site in Belgium. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2021-08-09.

Sponsored by University Hospital, Antwerp · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 1 year 1 month after the study started (first participant enrolled Jun 2020, registered Jul 2021).
Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
18 Years to 90 Years
Sex
All
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Study summary

A clinical trial investigating the effect of a combined locoregional anesthesia technique on the postoperative analgesia outcomes after a total hip arthroplasty. A PENG block will be used in combination with a LFCN block. The results will be compared to a control group that is solely treated with intravenous analgesia. This technique aims to provide improved pain scores after surgery without interference of revalidation.

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Conditions studied

  • Anesthesia, Conduction
  • Pain, Postoperative
  • Arthroplasty, Replacement, Hip

Browse trials for

Keywords

  • regional anesthesia
  • postoperative pain
  • total hip arthroplasty
  • pericapsular nerve group block
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In context

Pain, Postoperative

5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.

This study's enrollment of 40 is below the median of 75 across 4,344 interventional studies indexed under Pain, Postoperative.

Browse Pain, Postoperative studies →

Lead sponsor

University Hospital, Antwerp is the lead sponsor of 234 studies on the registry; 68 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • adult patients who underwent a primary total hip replacement under general anesthesia

Exclusion criteria

Exclusion Criteria:

  • insulin dependent diabetes mellitus
  • chronic pain
  • severe dementia or mental retardation
  • allergy to local anesthetics
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
40 participants (actual)

Study arms

  • Active comparator
    PENG + LFCN block

    The participants in this group received a combined regional technique just before surgery: * Pericapsular nerve group (PENG) block * Lateral femoral cutaneus nerve (LFCN) block

    Procedure: PENG + LFCN block · Drug: Ropivacaine injection

  • No intervention
    No regional anesthesia

    Control group

Interventions

  • ProcedurePENG + LFCN block

    Regional anesthesia technique

    Also known as: pericapsular nerve group block, lateral femoral cutaneous nerve block

  • DrugRopivacaine injection

    Local anesthetic used for peripheral nerve block.

    Also known as: ropivacaine 0.375%

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What researchers measure

Primary outcomes

  1. Initial pain score

    numeric rating score (NRS) of 0 to 10

    Time frame: 0 hours postoperative

  2. Pain score after 2h

    numeric rating score (NRS) of 0 to 10

    Time frame: 2 hours postoperative

  3. Pain score after 24h

    numeric rating score (NRS) of 0 to 10

    Time frame: 24 hours postoperative

Secondary outcomes

  1. Initial motor function

    score chart inspired by the Bromage score (NRS) of 0 to 3

    Time frame: 0 hours postoperative

  2. Motor function after 2h

    score chart inspired by the Bromage score (NRS) of 0 to 3

    Time frame: 2 hours postoperative

  3. Motor function after 24h

    score chart inspired by the Bromage score (NRS) of 0 to 3

    Time frame: 24 hours postoperative

  4. Intraoperative opioids

    dose of intravenous opioids in microgram per kilogram bodyweight

    Time frame: intraoperative

  5. Postoperative opioids

    dose of intravenous opioids in microgram per kilogram bodyweight

    Time frame: 24 hours postoperative

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Study locations

1 site
  • AZ Monica
    Deurne, Belgium
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References and documents

Publications

  • Giron-Arango L, Peng PWH, Chin KJ, Brull R, Perlas A. Pericapsular Nerve Group (PENG) Block for Hip Fracture. Reg Anesth Pain Med. 2018 Nov;43(8):859-863. doi: 10.1097/AAP.0000000000000847. PubMed 30063657 ↗
  • Morrison C, Brown B, Lin DY, Jaarsma R, Kroon H. Analgesia and anesthesia using the pericapsular nerve group block in hip surgery and hip fracture: a scoping review. Reg Anesth Pain Med. 2021 Feb;46(2):169-175. doi: 10.1136/rapm-2020-101826. Epub 2020 Oct 27. Erratum In: Reg Anesth Pain Med. 2022 May;47(5):e1. doi: 10.1136/rapm-2020-101826corr1. PubMed 33109730 ↗
  • Wainwright TW, Gill M, McDonald DA, Middleton RG, Reed M, Sahota O, Yates P, Ljungqvist O. Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS(R)) Society recommendations. Acta Orthop. 2020 Feb;91(1):3-19. doi: 10.1080/17453674.2019.1683790. Epub 2019 Oct 30. PubMed 31663402 ↗
  • Roy R, Agarwal G, Pradhan C, Kuanar D. Total postoperative analgesia for hip surgeries, PENG block with LFCN block. Reg Anesth Pain Med. 2019 Mar 28:rapm-2019-100454. doi: 10.1136/rapm-2019-100454. Online ahead of print. No abstract available. PubMed 30923252 ↗
  • Hojer Karlsen AP, Geisler A, Petersen PL, Mathiesen O, Dahl JB. Postoperative pain treatment after total hip arthroplasty: a systematic review. Pain. 2015 Jan;156(1):8-30. doi: 10.1016/j.pain.0000000000000003. PubMed 25599296 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 9, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04996290
Lead sponsor
University Hospital, Antwerp
Responsible party
Lennert De Schrijver (Principal Investigator, University Hospital, Antwerp) — Principal investigator
First posted
Aug 9, 2021
Start date
Jun 1, 2020
Primary completion
Sep 30, 2020
Completion
Oct 1, 2020
Last update
Aug 9, 2021

Study contacts

Yzabel Vandevivere, MD
principal investigator · AZ Monica

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2021. You cannot join it, but the record below documents what was studied.

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