An interventional study of arthroscopic micro-fracture with autologous adipose gel and arthroscopic micro-fracture in Articular Cartilage Defects, sponsored by Peking University Third Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2021-07-08.
Sponsored by Peking University Third Hospital · Not applicable, Interventional, and Treatment
66 articular cartilage injury diseases patients were divided into two groups as 1:1. The test group will be treated with arthroscopic micro-fracture with autologous adipose gel, and the control group will be treated with arthroscopic micro-fracture. Postoperative MRI evaluation, Lysholm score, IKDC score, Tegner score, and VAS score will be used as the treatment validity evaluation index, at the same time testing blood routine, blood biochemistry, urine routine, CRP, electrocardiogram and other laboratory tests and recording the occurrence of adverse events.
In this study, 66 patients who were clinically diagnosed as articular cartilage injury diseases were divided into test group and control group according to the ratio of 1:1. The test group will be treated with arthroscopic micro-fracture with autologous adipose gel, and the control group will be treated with arthroscopic micro-fracture. Postoperative MRI evaluation, Lysholm score, IKDC score, Tegner score, and VAS score will be used as the treatment validity evaluation index, at the same time testing blood routine, blood biochemistry, urine routine, CRP, electrocardiogram and other laboratory tests and recording the occurrence of adverse events.
Peking University Third Hospital is the lead sponsor of 735 studies on the registry; 262 are open to participants now.
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The experimental group will be treated with arthroscopic microfracture with autologous adipose gel.
Procedure: arthroscopic micro-fracture with autologous adipose gel
The control group will be treated with arthroscopic microfracture.
Procedure: arthroscopic micro-fracture
Fully cut the adipose tissue taken out under the arthroscopy, transfer the cut adipose tissue to a syringe connected with a double pass, push back and forth through the syringe to physically emulsify the adipose, and centrifuge to obtain the autologous adipose gel, and inject it into the lesion
Surgeons routinely perform international standard micro-fracture surgery to repair cartilage damage
Assessing a change of MRI Evaluation of Articular Cartilage Injury after Repair
Assessing a change of postoperative MRI evaluation with autologous fat glue combined with micro-fracture treatment or micro-fracture treatment articular cartilage injury
Time frame: Knee MRI examinations were performed on patients baseline, 5 days, 90 days, 180 days, and 365 days after operation.
Lysholm score
Assessing a change of Lysholm score between two groups of patients
Time frame: Lysholm score was tested for the two groups of patients' baseline, 5 days, 90 days, 180 days, and 365 days after operation.
IKDC score
Assessing a change of IKDC score between two groups of patients
Time frame: IKDC score was tested for the two groups of patients' baseline, 5 days, 90 days, 180 days, and 365 days after operation.
Tegner score
Assessing a change of Tegner score between two groups of patients
Time frame: Tegner score was tested for the two groups of patients' baseline, 5 days, 90 days, 180 days, and 365 days after operation.
VAS score
Assessing a change of VAS score between two groups of patients
Time frame: VAS score was tested for the two groups of patients' baseline, 5 days, 90 days, 180 days, and 365 days after operation.
This study is status unknown, as verified in Jul 2021. You cannot join it, but the record below documents what was studied.
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Peking University Third Hospital