An observational study in Thyroid Diseases, sponsored by Second Affiliated Hospital, School of Medicine, Zhejiang University. Status unknown at 2 sites in China. Open to female participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-06-29.
Sponsored by Second Affiliated Hospital, School of Medicine, Zhejiang University · Observational
Thyroid autoimmunity(TAI) per se have adverse effect on pregnancy outcomes，and aspirin and prednisone were used frequently in antithyroid antibodies(ATA) positive infertile women in clinical practice, but the impact of these medicines is still controversial. Therefore, aim of the study was to investigate whether or not the treatment of prednisone in addition to aspirin was capable of improving reproductive outcomes in euthyroid infertile women.
A multicenter retrospective study performed during the period of 2017 to 2020 and euthyroid infertile women positive for anti-thyroperoxidase antibody (TPOAb) and/or thyroglobulin antibody (TgAb) alone with thyroid stimulating hormone 0.35-4.0mIU/L undergoing first in vitro fertilization and embryo transfer(IVF-ET) cycle were recruited in our study.Data analysis was performed using the Statistics Package for Social Sciences.In the end, the value of prednisone plus aspirin treatment was investigated to make a big contribution on clinical practice.
967 studies on the registry are indexed under Thyroid Diseases; 197 are open to participants now.
This study's planned enrollment of 402 is above the median of 150 across 381 observational studies indexed under Thyroid Diseases.
Browse Thyroid Diseases studies →Second Affiliated Hospital, School of Medicine, Zhejiang University is the lead sponsor of 1,058 studies on the registry; 511 are open to participants now.
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Both TPOAb and TgAb in all the subjects were measured before ART procedure, and their thyroid stimulating hormone (TSH) level ranged from 0.35-4.0mIU/L and also they all underwent first embryo transfer without previous IVF history.
Exclusion Criteria:
aspirin: tablet 100mg qd 2-5weeks prednisone: tablet 10mg qd 2-5weeks
Drug: Prednisone 10 MG+aspirin 100MG
Discontinue medication based on early pregnancy outcome
clinical pregnancy rate
Clinical pregnancy was defined as the existence of a viable embryo within an intrauterine gestational sac
Time frame: 3 mouths
Plan to share: Undecided — uncertainty
No publications or documents are linked to this record.
This study is status unknown, as verified in Mar 2021. You cannot join it, but the record below documents what was studied.
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Second Affiliated Hospital, School of Medicine, Zhejiang University