An observational study in Nephrogenic Diabetes Insipidus, sponsored by Universitair Ziekenhuis Brussel. Completed at 1 site in Belgium. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-04-27.
Sponsored by Universitair Ziekenhuis Brussel · Observational
The investigators aim to retrospectively explore the electronic medical records of all patients who were admitted to the Intensive Care Unit (ICU) of the UZ Brussels in the last 10 years (March 1st 2011- March 1st 2021) and who received prolonged sedation (>24h) with sevoflurane.
Universitair Ziekenhuis Brussel is the lead sponsor of 374 studies on the registry; 106 are open to participants now.
Counted across the registry records on this site, refreshed daily.
all patients who were admitted to the Intensive Care Unit (ICU) of the UZ Brussels in the last 10 years (March 1st 2011- March 1st 2021) and who received prolonged sedation (>24h) with sevoflurane.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients that received sevoflurane while in ICU care.
Drug: Sevoflurane
Sevoflurane administration to sedate the patient
Nephrogenic Diabetes Insipidus prevalence
How many patients under sevoflurane sedation ultimately develop NDI? NDI confirmed by demonstrating the absence of a urine concentrating response to exogenous Arginine Vasopressine.
Time frame: up to 8 weeks
Number of patients that develop risk factors of NDI
Number of patients that develop risk factors (electrolyte disorder, urinary obstruction) for NDI.
Time frame: up to 8 weeks
Amount of time patient was placed under sevoflurane sedation.
How long are they under sevoflurane sedation.
Time frame: up to 8 weeks
Number of patients with electrolyte abnormalities as assessed by lab results.
Lab results of hematology and chemistry labs show an electrolyte imbalance.
Time frame: during hospitalization, up to 8 weeks.
Number of patients with excessive urine output
Amount of urine output: \>40 ml/kg/24h
Time frame: during hospitalization, up to 8 weeks.
Number of patients with an abnormal physical examination.
Typical physical symptoms of (N)DI: tired, lethargic, tachycardia, tachypnea, hypotension and dry mucous membranes.
Time frame: during hospitalization, up to 8 weeks.
Number of patients with urine with an abnormal osmolality
Lab testing of urine: osmolality \< 300 mosm/kg
Time frame: during hospitalization, up to 8 weeks.
Number of patients that show an abnormal amount of fluid intake
\>2.5l/day
Time frame: during hospitalization, up to 8 weeks.
Number of patients that have an abnormal abdominal echo of the bladder.
Echo shows an enlarged bladder.
Time frame: during hospitalization, up to 8 weeks.
Number of symptoms of NDI
Number of symptoms of NDI do these patients show?
Time frame: up to 8 weeks
Timing of symptoms of NDI
After how much time do these patients show symptoms of NDI?
Time frame: up to 8 weeks
Plan to share: Undecided
No publications or documents are linked to this record.
Ran from May 2021 to primary completion in Apr 2023, 22 months.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.
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Diabetes Insipidus, Nephrogenic
Universitair Ziekenhuis Brussel →