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Status unknownNCT04926714Updated Jun 23, 2021

Ophthalmologic Evaluation of Patients With Obesity and Metabolic Syndrome Before and After Bariatric Surgery

An observational study in Eye Diseases and Obesity Associated Disorder, sponsored by XiaoYong Liu. Status unknown at 1 site in China. Per ClinicalTrials.gov, last updated 2021-06-23.

Sponsored by XiaoYong Liu · Observational

The sponsor has not verified this record recently (last verified Jun 2021), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
200
Sex
All
01

Study summary

The aim of this study was to investigate the pathogenic role of obesity on blinding eye diseases in a population of severely obese patients with no history of eye diseases, and to verify whether weight loss induced by bariatric surgery may have a protective effect.

Read the detailed description

This was a pilot, monocentric, prospective, and open label study conducted at First Affiliated Hospital of Jinan Universityreceived.Patients with body mass index ≥ 32.5Kg/m2; or patients with body mass index of 27.5-32.5Kg/m2 and metabolic diseases were consecutively recruited.All participants underwent complete ophthalmological evaluation， Keratograph 5M and optical coherence tomography.Patients who underwent bariatric surgery were evaluated also 3 months, 6 months and 1 year after surgery.

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Conditions studied

  • Eye Diseases
  • Obesity Associated Disorder
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In context

Eye Diseases

740 studies on the registry are indexed under Eye Diseases; 117 are open to participants now.

This study's planned enrollment of 200 is above the median of 120 across 172 observational studies indexed under Eye Diseases.

Browse Eye Diseases studies →

Lead sponsor

XiaoYong Liu is the lead sponsor of 4 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

  1. Patients with BMI≥32.5Kg/m2Or patients with BMI27.5-32.5Kg/m2, combined with metabolic diseases;
  2. Subjects understand the purpose of the clinical study and are willing, able and committed to return to the study center for all clinical study visits and to complete all study procedures.

Inclusion criteria

  1. Patients with BMI≥32.5Kg/m2；
  2. patients with BMI27.5-32.5Kg/m2, combined with metabolic diseases;

Exclusion criteria

Exclusion Criteria:

  1. Patients with pre-existing ocular diseases or visual alterations were excluded to avoid confounding factors related to pre-existing retinal pathology, independent from obesity per se.
  2. Patients with dementia, Parkinson's disease, Alzheimer's disease, multiple sclerosis or other severe neurological diseases were also excluded since ophthalmologic parameters may be altered in these conditions.
  3. Patients with lens opacities that made impossible the posterior segment examination, or with a refractive error > +5 or \<-8 diopters spherical equivalent were also excluded.
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
200 participants (estimated)
Target follow-up
1 Year
Patient registry
Yes
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What researchers measure

Primary outcomes

  1. optical coherence tomography

    Time frame: 12 months

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Study locations

1 of 1 sites recruiting
  • The First Affiliated Hospital of Jinan University
    Guangzhou, Guangdong 510630, China
    • xiaoyong Liu · Contact · jndxlxy@163.com · 13760638809
    • xiaoyong Liu · Principal investigator
    Recruiting
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 23, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04926714
Lead sponsor
XiaoYong Liu
Responsible party
XiaoYong Liu (Deputy chief physician of opthalmology, The First Affiliated Hospital of Jinan University, First Affiliated Hospital of Jinan University) — Sponsor-investigator
First posted
Jun 15, 2021
Start date
May 17, 2021
Primary completion
Apr 30, 2023 (estimated)
Completion
Apr 30, 2023 (estimated)
Last update
Jun 23, 2021

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jun 2021. You cannot join it, but the record below documents what was studied.

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