An interventional study of High intensity light box for bright light therapy and single vision spectacle lenses and High intensity light box for bright light therapy and Defocus Incorporated Multiple Segments (DIMS) spectacle lenses in Myopia, sponsored by The Hong Kong Polytechnic University. Completed at 1 site in Hong Kong. Open to participants aged 7 Years to 12 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-12.
Sponsored by The Hong Kong Polytechnic University · Not applicable, Interventional, and Treatment
The purpose of the study is to investigate the effect of bright light therapy, myopic defocus, atropine and the combination in myopia control in schoolchildren.
The present study is a multi-arm randomised clinical trial with a 24-month duration. Subjects will be healthy Hong Kong Chinese schoolchildren with low to moderate myopia. The aims are to determine the clinical effectiveness of bright light therapy on inhibiting myopia progression in schoolchildren, and to determine whether combination therapy using bright light therapy (BLT) and myopic defocus is more effective than monotherapy.
Study population Seven hundred and sixty Hong Kong Chinese children (152 in each) of A. Control group, B. BLT only group, C. BLT and Defocus Incorporated Multiple Segments (DIMS) group, D. BLT and atropine 0.01% group) and E. Atropine 0.01% group aged 7-12 years old will be recruited. They must not have had prior or current myopia control treatment, have no ocular or systemic diseases/abnormalities that affect visual function, refractive development or spectacle lens wear, and no previous intraocular or corneal surgery. They must not have allergy to atropine.
The eligible subjects will be randomly assigned into one of the four groups. Their cycloplegic refraction and axial length will be monitored every six months for 2 years. The changes in refractive errors and axial length between groups will be compared.
984 studies on the registry are indexed under Myopia; 210 are open to participants now.
This study's enrollment of 577 is above the median of 80 across 783 interventional studies indexed under Myopia.
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Exclusion Criteria:
Subjects in control will receive single vision spectacle lenses and a placebo desk lamp
Subjects in BLT monotherapy group will receive a high intensity light box for bright light therapy and single vision spectacle lenses
Other: High intensity light box for bright light therapy and single vision spectacle lenses
Subjects in BLT and DIMS group will receive a high intensity light box for bright light therapy and Defocus Incorporated Multiple Segments (DIMS) spectacle lenses
Other: High intensity light box for bright light therapy and Defocus Incorporated Multiple Segments (DIMS) spectacle lenses
Subjects in BLT and atropine group will receive a high intensity light box for bright light therapy, single vision spectacle lens, and atropine 0.01% eye drop (twice a day)
Other: High intensity light box for bright light therapy and atropine 0.01% eye drop and and single vision spectacle lenses
Subjects in atropine group will receive atropine 0.01% eye drop (twice a day) and single vision spectacle lenses
Other: Atropine 0.01% eye drop and and single vision spectacle lenses
High intensity light box for bright light therapy and single vision spectacle lenses
High intensity light box for bright light therapy and Defocus Incorporated Multiple Segments (DIMS) spectacle lenses
High intensity light box for bright light therapy and atropine 0.01% eye drop and and single vision spectacle lenses
Atropine 0.01% eye drop and and single vision spectacle lenses
Cycloplegic Refraction Change in spherical equivalent refraction (SER)
Change in cycloplegic SER (in diopter) will be measured using an open field autorefractor
Time frame: Baseline and 2 years
Axial length
Axial length (mm) will be measured after cycloplegia using a non-contact optical biometer
Time frame: Baseline and 2 years
Plan to share: No
This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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The Hong Kong Polytechnic University