An observational study in Pancreaticoduodenectomy and Fatigue, sponsored by Peking University People's Hospital. Completed at 1 site in China. Per ClinicalTrials.gov, last updated 2021-05-12.
Sponsored by Peking University People's Hospital · Observational
Surgeons sometimes need to work overtime or even stay up late to perform pancreaticoduodenectomy. Fatigue and sleep deprivation can result in an increased error rate at work. The effect of overtime work for pancreaticoduodenectomy on the prognosis of patients is unclear. The study explores the impact of overtime work for pancreaticoduodenectomy on the prognosis of patients.
This was a single-center, retrospective study. The patients who underwent pancreaticoduodenectomy in Peking University People's Hospital between 2017 and 2019 were included. Patients were stratified by operative start time into the control group (surgery that started between 8:00 and 16:49) and the overtime group (surgery that started between 17:00 and 22:00) and compared intraoperative and postoperative parameters to clarify the impact of overtime surgery on the short-term prognosis of patients.
Research Background Due to the large number of operations, surgeons sometimes need to work overtime to perform elective surgery. At this time, surgeons need to perform the operation under fatigue or even sleep deprivation. Fatigue and sleep deprivation will affect the cognitive function, leading an increased error rate at work. There have been numerous studies about the effect of overtime surgery on the prognosis of patients. However, the impact of surgery on patients under fatigue and sleep deprivation is still controversial. Halvachizadeh et al. observed higher complication and mortality rates for orthopedic trauma surgery performed after-hours. Boscà et al. believe that there is no poor prognosis in patient undergoing liver transplantation by a fatigued surgeons. Brunschot et al. reported that nighttime kidney transplantation is associated with less pure technical graft failure.
Pancreaticoduodenectomy is widely used to treat pancreatic cancer, bile duct carcinoma, duodenal carcinoma, and ampullary carcinoma. The operation is complicated, and usually lasts more than 5 hours. Postoperative complications such as pancreatic fistula, gastroparesis, abdominal infection, and abdominal hemorrhage are prone to occur. Extensive literature have clarified the risk factors related to complications after pancreaticoduodenectomy. At present, there is no report on the effect of pancreaticoduodenectomy under overtime on the prognosis of patients. Therefore, the study explores the impact of overtime work for pancreaticoduodenectomy on the prognosis of patients.
1,859 studies on the registry are indexed under Fatigue; 376 are open to participants now.
This study's enrollment of 235 is above the median of 100 across 367 observational studies indexed under Fatigue.
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patients who underwent pancreaticoduodenectomy at the Department of Hepatobiliary Surgery, Peking University People's Hospital from January 2017 to December 2019
Exclusion Criteria:
Patients who started surgery between 8:00 and 16:59 were included in the control group.
Other: Overtime pancreaticoduodenectomy
Patients who started surgery from 17:00 to 22:00 were included in the overtime group.
Other: Overtime pancreaticoduodenectomy
Compared with daytime surgery, the intervention in this study is to work overtime after 17:00 to perform pancreaticoduodenectomy.
Operative time
The time elapsed from the patient's opening to closing the abdomen
Time frame: Intraoperative
Postoperative complication rate
Postoperative complications include pancreatic fistula, gastric emptying disorder, abdominal cavity infection, and non-surgical-related complications.
Time frame: 1 year
Blood loss
The amount of bleeding of the patient during the operation
Time frame: Intraoperative
Plan to share: No — Data cannot be publicly available due to regulations of the Ethics Committee of Peking University People's Hospital. But the data can be available from the researcher on reasonable request.
This study is completed, as verified in May 2021. You cannot join it, but the record below documents what was studied.
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