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CompletedNCT04879836Updated Jul 7, 2021

Effects of a Gum Gel Intended to Treat Signs and Symptoms of Teething

An observational study in Tooth Eruption Disorder, sponsored by University of Urbino "Carlo Bo". Completed at 1 site in Italy. Open to participants aged 2 Months to 12 Months. Per ClinicalTrials.gov, last updated 2021-07-07.

Sponsored by University of Urbino "Carlo Bo" · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
51
Ages
2 Months to 12 Months
Sex
All
01

Study summary

Teething discomfort is a widespread disorder affecting a very high percentage of infants. The use of hyaluronic acid gels has been shown in the last 20 years to be an effective tool, generally devoid of side effects, in reducing oral mucosal inflammation in adults. Its effectiveness in infants is affected by the strength of hyaluronic acid retention over the oral mucosa. This is in turn affected by formulation and may vary between different products due to the different ingredients used. In this study, the results collected by monitoring the paediatric experience regarding a newly developed HA-based medical device, intended to counteract teething discomfort in infants, will be reported.

02

Conditions studied

  • Tooth Eruption Disorder

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Keywords

  • gums
  • redness
  • fever
  • paediatric
  • inappetence
  • sleep disturbance
03

Who can participate

Ages eligible
2 Months to 12 Months
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Infants, without ethnic limitations, of both sexes and between the ages of 2 and 12 months, affected by teething discomfort but considered otherwise healthy.

Inclusion criteria

  • Teething discomfort
  • Being healthy (except for teething discomfort)

Exclusion criteria

Exclusion Criteria:

  • Being placed on one of the following therapies in the 45 days prior to the beginning of the study: immunosuppressive, cytotoxic, cortisone, antibiotics, antifungal and hormone therapy
04

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
51 participants (actual)
Patient registry
No

Groups and cohorts

  • Teething Ring + Teething Gel

    Device: Teething Gel · Device: Teething Ring

  • Teething Ring

    Device: Teething Ring

Interventions

  • DeviceTeething Gel

    Dosage: application of an even coat of 1mm thickness Frequency: 5 times/day (after main meals and before sleeping) Duration: 4 weeks

  • DeviceTeething Ring

    The teething ring was filled with a coolant Usage: 5/10 min per time Frequency: 5 times/day Duration: 4 weeks

05

What researchers measure

Primary outcomes

  1. Unexplained cry

    5-level Likert scale completed by the paediatrician

    Time frame: 1 month (1 check per week)

  2. Irritability

    5-level Likert scale completed by the paediatrician

    Time frame: 1 month (1 check per week)

  3. Sleep disturbance

    5-level Likert scale completed by the paediatrician

    Time frame: 1 month (1 check per week)

  4. Inappetence

    5-level Likert scale completed by the paediatrician

    Time frame: 1 month (1 check per week)

  5. Salivation

    5-level Likert scale completed by the paediatrician

    Time frame: 1 month (1 check per week)

  6. Gum redness

    5-level Likert scale completed by the paediatrician

    Time frame: 1 month (1 check per week)

  7. Fever

    Number of days with fever

    Time frame: 1 month (1 check per week)

  8. General well-being

    5-level Likert scale completed by the paediatrician

    Time frame: 1 month (1 check per week)

06

Study locations

1 site
  • University of Urbino Carlo Bo
    Urbino, 61029, Italy
07

Registry details

Key details

Study ID
NCT04879836
Lead sponsor
University of Urbino "Carlo Bo"
Responsible party
Davide Sisti (PhD, University of Urbino "Carlo Bo") — Principal investigator
First posted
May 10, 2021
Start date
Dec 1, 2018
Primary completion
Jun 30, 2019
Completion
Jun 30, 2019
Last update
Jul 7, 2021

Study contacts

Davide Sisti, PhD
principal investigator · University of Urbino "Carlo Bo"

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jul 2021. You cannot join it, but the record below documents what was studied.

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