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RecruitingNCT04851925Updated Jan 5, 2024

MR Fingerprinting for Vestibular Schwannomas

An observational study in Vestibular Schwannoma, sponsored by Medical University of Vienna. Recruiting at 1 site in Austria. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2024-01-05.

Sponsored by Medical University of Vienna · Observational

From the registry’s dates

  • Primary completion was expected by Dec 2025, 9 months ago, but the record still lists the study as recruiting.
  • Started Feb 2021; still recruiting 5 years 7 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
50
Ages
18 Years to 90 Years
Sex
All
01

Study summary

MR Fingerprinting (MRF) will be performed in patients who will be treated with Gamma Knife radio surgery for a vestibular schwannoma before the intervention. Fifty patients will be included with a vestibular schwannoma of minimum 1cm in size. During follow-up, response of the tumor to radiosurgery will be evaluated for each patient with MRI. The aim of the study is to find patterns of vestibular schwannomas in MRF data which correlate with the type of response to radio surgery, i.e. tumor control after radiosurgery, further tumor growth despite radiosurgery, cystic transformation after radiosurgery.

02

Conditions studied

  • Vestibular Schwannoma
03

In context

Neurilemmoma

82 studies on the registry are indexed under Neurilemmoma; 21 are open to participants now.

This study's planned enrollment of 50 is below the median of 63 across 30 observational studies indexed under Neurilemmoma.

Browse Neurilemmoma studies →

Lead sponsor

Medical University of Vienna is the lead sponsor of 1,076 studies on the registry; 177 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Sampling method
Probability sample

Study population

Patients with vestibular schwannoma of minimum 1cm, who will undergo Gamma Knife radiosurgery

Eligibility criteria

Inclusion Criteria: Planned Gamma Knife radiosurgery for vestibular schwannoma of minimum 1cm in size -

Exclusion Criteria: Vestibular Schwannoma of less than 1cm in size. Other a priori treatment than Gamma Knife radiosurgery

-

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
50 participants (estimated)
Patient registry
No

Interventions

  • OtherMR Fingerprinting

    Specific Magnetic Resonance Imaging protocol

06

What researchers measure

Primary outcomes

  1. Tumor control

    Number of patients without further growth of the tumor on follow-up MRI after radiosurgery

    Time frame: 3 years

  2. Tumor growth

    Number of patients with growth of the tumor on follow-up MRI after radiosurgery

    Time frame: 3 years

  3. Cystic transformation

    Number of patients with cystic transformation of the tumor on follow-up MRI after radiosurgery

    Time frame: 3 years

07

Study locations

1 of 1 sites recruiting
  • Medical University of Vienna
    Vienna, 1090, Austria
    • Josa Frischer, MD · Contact · josa.frischer@meduniwien.ac.at · +4314040045500
    • Dorian Hirschmann, MD · Contact · dorian.hirschmann@meduniwien.ac.at · +4314040025780
    • Dorian Hirschmann, MD · Sub investigator
    • Josa M Frischer, MD · Principal investigator
    • Gilbert Hangel, DI · Sub investigator
    • Brigitte Gatterbauer, MD · Sub investigator
    • Anna Cho, MD · Sub investigator
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 5, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04851925
Lead sponsor
Medical University of Vienna
Responsible party
Josa M Frischer, MD, PhD (Principal Investigator, Medical University of Vienna) — Principal investigator
First posted
Apr 21, 2021
Start date
Feb 24, 2021
Primary completion
Dec 24, 2025 (estimated)
Completion
Dec 24, 2025 (estimated)
Last update
Jan 5, 2024

Study contacts

Dorian Hirschmann, MD
Contact
dorian.hirschmann@meduniwien.ac.at
+4314040025780
Josa Frischer, MD
Contact
josa.frischer@meduniwien.ac.at
+4314040045500
Josa Frischer, MD
principal investigator · Medical University of Vienna

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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