An observational study in Undernutrition, Eating Disorders and Underweight, sponsored by University of Glasgow. Completed at 1 site in United Kingdom. Open to participants aged 1 Year to 16 Years. Per ClinicalTrials.gov, last updated 2022-04-07.
Sponsored by University of Glasgow · Observational
This is a pilot study of children attending the Glasgow feeding clinic (GFC) which looks after a range of children with severe feeding problems who commonly have low appetite and extreme thinness. The investigators want to find out if these children are more likely to carry genetic markers of thinness.
Thinness occurs as a result of undereating, but it is not always clear why an individual child has not eaten enough, or how to get them to eat more. There is a need to understand the child characteristics that predispose to undereating and the how these operate, in order to design more effective treatment and prevention programmes. The Glasgow feeding clinic (GFC) looks after a range of children with severe feeding problems who commonly have low appetite and extreme thinness. The investigators want to find out if these children are more likely to carry genetic markers of thinness.
The investigators will invite up to 60 families to complete a standardised online questionnaire (ICFET) about their child's eating behaviour and collect a saliva sample from their child, sent by post. The investigators will identify how many genetic markers for thinness each carries and relate this to their ICFET appetite scores and existing growth measurements as well as their feeding history.
1,277 studies on the registry are indexed under Malnutrition; 230 are open to participants now.
This study's enrollment of 25 is below the median of 206 across 393 observational studies indexed under Malnutrition.
Browse Malnutrition studies →University of Glasgow is the lead sponsor of 145 studies on the registry; 21 are open to participants now.
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This is a heterogeneous population, united by their difficulties in eating solid food. The majority are, or have previously been, tube fed and around half have some learning disability. Thinness is very common in this group, but we will include all children, whatever their current growth pattern.
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All participants currently attending Glasgow Feeding Clinic or assessed there within the last 2 years. NB current ethical application is restricted to children aged 1-7 years, but the investigators plan to apply to extend that to age 16 years.
Exclusion Criteria:
Sample not to be collected with 2 weeks of any symptoms or recent contact with Covid 19
These children have all attended a multidisciplinary feeding clinic with severe food refusal and were commonly receiving tube feeding or supplement drinks. The clinic helps children progress onto a normal oral diet
Also known as: tube weaning
Genotype risk score
This the number of risk polymorphisms present for each child ranges from 0-20. a high score suggests more thinness
Time frame: Within 1-2 months of recruitment
Eating behaviour score
Measure of appetite and food refusal assessed using standard questionnaire (International Complementary Feeding Evaluation Tool (ICFET) Score from 1-5, hihger score suggests greater avidity
Time frame: At recruitment or up to 2 months before
Body mass index
weight (kg)/Height (m) squared
Time frame: Up to two years before genetic test
Plan to share: Yes — The individual anonymized data would be made available on request for a collaborative genetic study
Supporting information: Study protocol, Informed consent form
Time frame: On request once initial write up is complete - after 2 years
Access criteria: Available on request
No publications or documents are linked to this record.
Ran from May 2021 to primary completion in Dec 2021, 7 months.
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This study is completed, as verified in Mar 2022. You cannot join it, but the record below documents what was studied.
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