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CompletedNCT04834453Updated Jul 21, 2022

Correlation of Trans Cranial Doppler Ultrasound and CT Scan in Monitoring of Posttraumatic Brain Edema

An observational study in Brain Edema, sponsored by Ain Shams University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2022-07-21.

Sponsored by Ain Shams University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
32
Ages
18 Years to 60 Years
Sex
All
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Study summary

The most common tool for diagnosis and follow up of cerebral edema in ICU is brain CT scan that necessitate patient transportation with risk of hemodynamic instability, and exposure to radiation.

Transcranial Doppler (TCD) sonography allows true and rapid imaging of blood flow velocities of intracranial vessels. Transcranial Doppler sonography provides noninvasive evaluation of intracranial pressure by its characteristic wave patterns

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Conditions studied

  • Brain Edema

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03

In context

Brain Edema

102 studies on the registry are indexed under Brain Edema; 25 are open to participants now.

This study's enrollment of 32 is below the median of 88 across 31 observational studies indexed under Brain Edema.

Browse Brain Edema studies →

Lead sponsor

Ain Shams University is the lead sponsor of 1,950 studies on the registry; 429 are open to participants now.

Of its 35 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Sampling method
Probability sample

Study population

Patients with isolated blunt TBI from (age 18-60 years) of both sex, will be included in the study and followed prospectively. Severity of trauma is evaluated by GCS, Rotterdam computed tomography score (CTS) care system with the help of our radiodiagnosis colleagues

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • isolated blunt Traumatic Brain Injury
  • age 18-60 years

Exclusion criteria

Exclusion Criteria:

  • Pregnancy
  • Intracerebral hemorrhage
  • Patients whose blood flow velocities could not be obtained from Trans temporal acoustic bone windows.
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
32 participants (actual)
Patient registry
No

Interventions

  • Diagnostic testtranscranial ultrasound

    - Transcranial Doppler sonography will be performed with the patients in the supine position., using low frequency probe of 2 MHz will be placed on temporal bone- will be performed daily

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What researchers measure

Primary outcomes

  1. the correlation between CCT scans score and Pulsatility Index of each patient

    Time frame: 7 days

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Study locations

1 site
  • Ain Shams University
    Cairo, Egypt
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Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Apr 2021 to primary completion in Nov 2021, 6 months.

Of 15 observational studies under Brain Edema, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 32. This study's 6 months is below that.

How these figures are worked out, and which studies are left out of them.

Registered
Apr 4, 2021
First posted
Apr 8, 2021
StartActual
Apr 28, 2021
Primary completionActual
Nov 10, 2021
CompletionActual
Dec 28, 2021
Last update
Jul 21, 2022
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jul 21, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04834453
Responsible party
Mona Ammar (Assistant professor, Ain Shams University) — Principal investigator
First posted
Apr 8, 2021
Start date
Apr 28, 2021
Primary completion
Nov 10, 2021
Completion
Dec 28, 2021
Last update
Jul 21, 2022

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.

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Discussion

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