An interventional study of Normal saline and Hyaluronic acid in Preventing Postextraction Complication, sponsored by Al-Azhar University. Completed at 1 site in Saudi Arabia. Open to participants aged 20 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-07-22.
Sponsored by Al-Azhar University · Not applicable, Interventional, and Treatment
Impacted mandibular 3rd molar will be extracted in all patients, then patients will be divided, according to material placed in extraction socket into 3 groups: control, hyaluronic acid and honey. Then post extraction complications will be evaluated
Impacted Mandibular third molar will be extracted under local anesthesia Through standard surgical flap elevation, after extraction and wound irrigation a material facilitate healing will be placed. According to material will be placed patients will be divide into 3 group: control ( no material, second group hyaluronic acid, third group ( honey).. then wound will be closed. Postoperative pain ( through visual analog scale) , edema, total dose of analgesic, mandibular movement (interincisal distance in mm) will be evaluated preoperative, 1,2,3,7, and 10 day after extraction
195 studies on the registry are indexed under Tooth, Impacted; 20 are open to participants now.
This study's enrollment of 72 is above the median of 53 across 164 interventional studies indexed under Tooth, Impacted.
Browse Tooth, Impacted studies →Al-Azhar University is the lead sponsor of 505 studies on the registry; 167 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Normal saline irrigation after extraction and No drug placed in tooth socket
Drug: Normal saline
Gengigel (Hyaluronic acid) placed after extraction
Drug: Hyaluronic acid
Methylprednisolone will be given intravenous to a patient half an hour before the surgery
Drug: Methylprednisolone
Methylprednisolone will be given intravenous to a patient half an hour before the surgery and Gengigel (Hyaluronic acid) placed after extraction
Drug: Methylprednisolone and Hyaluronic acid
Normal saline irrigation and No other drug placed after extraction
Immediately after removal of impacted tooth (hyaluronic acid) placed in extraction socket
Also known as: Gengigel
Methylprednsolone will be injected half an hour preoperatively
Methylprednisolone will be injected half an hour preoperatively and Immediately after removal of impacted tooth (hyaluronic acid) placed in extraction socket
Interincisal distance
Measuring distance between upper lower anterior teeth in mm
Time frame: Baseline (Preoperative)
Interincisal distance
Measuring distance between upper lower anterior teeth in mm
Time frame: 1 day postoperative
Interincisal distance
Measuring distance between upper lower anterior teeth in mm
Time frame: 2nd day postoperative
Interincisal distance
Measuring distance between upper lower anterior teeth in mm
Time frame: 3rd day postoperative
Interincisal distance
Measuring distance between upper lower anterior teeth in mm
Time frame: 7th day postoperative
Assessment of pain using Visual analog scale
Patient asked to describe pain intensity subjectively on visual analog scale where 0 mean no pain while 10 mean sever pain
Time frame: Baseline (Preoperative)
Assessment of pain using Visual analog scale
Patient asked to describe pain intensity subjectively on visual analog scale where 0 mean no pain while 10 mean sever pain
Time frame: 1st day
Assessment of pain using Visual analog scale
Patient asked to describe pain intensity subjectively on visual analog scale where 0 mean no pain while 10 mean sever pain
Time frame: 2nd day
Assessment of pain using Visual analog scale
Patient asked to describe pain intensity subjectively on visual analog scale where 0 mean no pain while 10 mean sever pain
Time frame: 3rd day
Assessment of pain using Visual analog scale
Patient asked to describe pain intensity subjectively on visual analog scale where 0 mean no pain while 10 mean sever pain
Time frame: 7th day
Total amount of analgesic
Total amount of analgesic Will be calculated
Time frame: 1st day postoperative
Total amount of analgesic
Total amount of analgesic Will be calculated
Time frame: 2nd day postoperative
Total amount of analgesic
Total amount of analgesic Will be calculated
Time frame: 3rd day postoperative
Total amount of analgesic
Total amount of analgesic Will be calculated
Time frame: 7th day postoperative
Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle
Edema measured from gonial angle and Tragus to mental, angle of mouth, ala of nose, and lateral canthus of eye respectively
Time frame: Baseline
Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle
Edema measured from gonial angle and Tragus to mental, angle of mouth, ala of nose, and lateral canthus of eye respectively
Time frame: 1st day postoperative
Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle
Edema measured from gonial angle and Tragus to mental, angle of mouth, ala of nose, and lateral canthus of eye respectively
Time frame: 2nd day postoperative
Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle
Edema measured from gonial angle and Tragus to mental, angle of mouth, ala of nose, and lateral canthus of eye respectively
Time frame: 3rd day postoperative
Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle
Edema measured from gonial angle and Tragus to mental, angle of mouth, ala of nose, and lateral canthus of eye respectively
Time frame: 7th day postoperative
This study is completed, as verified in Jul 2021. You cannot join it, but the record below documents what was studied.
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Al-Azhar University