An observational study in Necrotizing Enterocolitis, Neonate and Surgery, sponsored by Daping Hospital and the Research Institute of Surgery of the Third Military Medical University. Status unknown at 1 site in China. Open to participants aged 1 Hour to 44 Weeks. Per ClinicalTrials.gov, last updated 2022-10-14.
Sponsored by Daping Hospital and the Research Institute of Surgery of the Third Military Medical University · Observational
Necrotizing enterocolitis(NEC) is one of the most serious disease in the newborn infants, and two and more grades of NEC usually lead to surgery, even death. But, it is difficult to predict when to operate the surgery.
Necrotizing enterocolitis(NEC) is characterized by vomit, abdominal distention, hypoactive bowel sounds and bloody stools, even shock, disseminated intravascular coagulation(DIC) and sepsis. X-ray is shown Intestinal wall gas and/or portal vein pneumatosis and pneumoperitoneum.
Two and more grades of NEC in newborn infant is a urgent condition, and whether or not operation is difficult to predict.
Here, the investigators develop a score system including five parameters(abdominal circumference, base excess, heart rate, severities of respiratory distress, sepsis) in one retrospective cohort, and the score system is used and assessed to predict the need for surgery in another prospective cohort.
216 studies on the registry are indexed under Enterocolitis; 26 are open to participants now.
This study's planned enrollment of 800 is above the median of 78 across 86 observational studies indexed under Enterocolitis.
Browse Enterocolitis studies →Daping Hospital and the Research Institute of Surgery of the Third Military Medical University is the lead sponsor of 115 studies on the registry; 41 are open to participants now.
Counted across the registry records on this site, refreshed daily.
two and more of NEC is diagnosed in newborn infants during hospitalization
Exclusion Criteria:
two and more grades of NEC is assessed using the usual method to predict the need for surgery
Other: score system to predict the need for surgery · Other: usual method to predict the need for surgery
two and more grades of NEC is assessed using the score system to predict the need for surgery
Other: score system to predict the need for surgery · Other: usual method to predict the need for surgery
two and more grades of NEC is assessed using the score system to predict the need for surgery
two and more grades of NEC is assessed using the usual method to predict the need for surgery
sensitivity of the score system for predicting the need of surgery
sensitivity of the score system for predicting the need of surgery is assessed
Time frame: before surgery
specificity of the score system for predicting the need of surgery
specificity of the score system for predicting the need of surgery is assessed
Time frame: before surgery
accuracy of the score system for predicting the need of surgery
accuracy of the score system for predicting the need of surgery is assessed
Time frame: before surgery
positive likelihood ratio of the score system for predicting the need of surgery
positive likelihood ratio of the score system for predicting the need of surgery is assessed
Time frame: before surgery
negative likelihood ratio of the score system for predicting the need of surgery
negative likelihood ratio of the score system for predicting the need of surgery is assessed
Time frame: before surgery
positive predictive value of the score system for predicting the need of surgery
positive predictive value of the score system for predicting the need of surgery is assessed
Time frame: before surgery
negative predictive value of the score system for predicting the need of surgery
negative predictive value of the score system for predicting the need of surgery is assessed
Time frame: before surgery
This study is status unknown, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.
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Daping Hospital and the Research Institute of Surgery of the Third Military Medical University