An interventional study of Comprehensive swallowing rehabilitation and Swallowing education in Multiple System Atrophy, sponsored by Seoul National University Hospital. Recruiting at 1 site in South Korea. Open to participants aged 19 Years and older. Per ClinicalTrials.gov, last updated 2026-04-27.
Sponsored by Seoul National University Hospital · Not applicable, Interventional, and Treatment
The purpose of this study is to investigate the effect of comprehensive swallowing rehabilitation in patients with multiple system atrophy.
Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease characterized by parkinsonism, cerebellar syndrome, and autonomic failure. Dysphagia is a clinically significant symptom leading to pneumonia that causes death in patients with MSA. Although the symptoms of dysphagia in the two subtypes of MSA-the parkinsonian variant and the cerebellar variant- are different, there is no significant difference in the latency to onset of tube feeding. Therefore, effective intervention is needed to improve the safety and efficiency of swallowing regardless of the subtypes of MSA.
Although swallowing rehabilitation has been widely applied for swallowing disorders in patients with MSA, few studies have reported the clinical effect of applying swallowing therapy. Comprehensive swallowing rehabilitation has focused on functional muscle training, compensatory swallowing maneuvers, and thermal-tactile stimulation, which is used to treat dysphagia from stroke, Parkinson's disease, and head and neck cancer. Therefore, this study aims to investigate the effect of comprehensive swallowing rehabilitation in patients with MSA.
207 studies on the registry are indexed under Multiple System Atrophy; 73 are open to participants now.
This study's planned enrollment of 24 is below the median of 41 across 134 interventional studies indexed under Multiple System Atrophy.
Browse Multiple System Atrophy studies →Seoul National University Hospital is the lead sponsor of 1,900 studies on the registry; 274 are open to participants now.
Of its 12 completed or terminated interventional studies of FDA-regulated products, 2 (17%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: Comprehensive swallowing rehabilitation
Other: Swallowing education
The treatment time per session is 30 minutes. Total 12 sessions are provided for 6 weeks.
The education is 30 minutes. Total 1 session is provided immediately after baseline evaluation.
Penetration-Aspiration Scale
Time frame: at 6 weeks
Videofluoroscopic dysphagia scale
Time frame: at 6 weeks
Penetration-Aspiration Scale
Time frame: at 12 weeks
Videofluoroscopic dysphagia scale
Time frame: at 12 weeks
Peak Cough Flow
Time frame: at 6 weeks, at 12 weeks
Maximal Inspiratory Pressure
Time frame: at 6 weeks, at 12 weeks
Maximal Expiratory Pressure
Time frame: at 6 weeks, at 12 weeks
Forced vital capacity
Time frame: at 6 weeks, at 12 weeks
Forced expiratory volume
Time frame: at 6 weeks, at 12 weeks
Maximal phonation time
Time frame: at 6 weeks, at 12 weeks
Swallowing disturbance questionnaire
Time frame: at 6 weeks, at 12 weeks
Swallowing Quality of Life questionnaire
Time frame: at 6 weeks, at 12 weeks
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