An observational study in Covid19, sponsored by Maimónides Biomedical Research Institute of Córdoba. Status unknown at 10 sites in Spain. Per ClinicalTrials.gov, last updated 2021-02-26.
Sponsored by Maimónides Biomedical Research Institute of Córdoba · Observational
The aim of this study is prospectively analyzing the histopathological, ultrastructural and microbiological findings from autopsies performed on patients with COVID-19.
The aim of this study is to increase the knowledge of the pathogenic mechanisms of the COVID-19 disease, that will allow us to improve the design of clinical and therapeutic strategies against the disease. This is the tool to improve the prognosis of patients with COVID-19.
The performance of systematic and regulated autopsies can help to manage it. However, despite the need to generate this knowledge and the strong impact on mortality caused by the COVID-19 pandemic, the evidence from post-mortem studies is very limited.
7,638 studies on the registry are indexed under COVID-19; 488 are open to participants now.
This study's planned enrollment of 50 is below the median of 260 across 3,135 observational studies indexed under COVID-19.
Browse COVID-19 studies →Maimónides Biomedical Research Institute of Córdoba is the lead sponsor of 78 studies on the registry; 20 are open to participants now.
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Patients with COVID-19 infection confirmed by PCR, whose death is related to active COVID-19 infection or its complications.
Exclusion Criteria:
Patients with COVID-19 infection confirmed by PCR, whose death is related to active COVID-19 infection or its complications.
Other: Autopsy
The subjects deceased will undergo an autopsy to analyze the histopathological, ultrastructural and microbiological findings, related to the COVID-19 disease.
Histopathological and ultra-structural findings
To analyze the histopathological and ultra-structural findings obtained in complete and systematic autopsies of patients who died due to COVID-19.
Time frame: End of autopsy
Molecular characterization
To analyze the presence and molecular characterization of COVID-19 in the different organs obtained in autopsies of patients deceased by COVID-19.
Time frame: End of autopsy
Hidden pulmonary superinfections
To evaluate the frequency of hidden pulmonary superinfections (bacterial and fungal disease) in patients who died due to COVID-19.
Time frame: End of autopsy
Histopathological / ultra-structural findings and clinical / biological expression correlation
To correlate the histopathological and ultra-structural findings obtained in autopsies with the clinical and biological expression of patients who died due to COVID-19.
Time frame: End of autopsy
Plan to share: Yes — All the information collected will be shared with other researchers under request.
Supporting information: Study protocol, Sap, Icf, Csr
No publications or documents are linked to this record.
This study is status unknown, as verified in Feb 2021. You cannot join it, but the record below documents what was studied.
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Maimónides Biomedical Research Institute of Córdoba