CClinicalTrials.gg
Status unknownNCT04752865Updated Mar 1, 2023

Effects of Cytotoxic Chemotherapy and PARP Inhibition on the Genomic Contexture of Ovarian Cancer

An observational study in Ovarian Cancer, sponsored by Hellenic Cooperative Oncology Group. Status unknown at 1 site in Greece. Open to female participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2023-03-01.

Sponsored by Hellenic Cooperative Oncology Group · Observational

The sponsor has not verified this record recently (last verified Aug 2022), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Other
Time perspective
Retrospective
Enrollment
50
Ages
18 Years to 80 Years
Sex
Female
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Study summary

EFFECTS OF CYTOTOXIC CHEMOTHERAPY AND PARP INHIBITION ON THE GENOMIC CONTEXTURE OF OVARIAN CANCER: TR_NACT_OV/17 In order to approach the above open questions, ultimately aiming in understanding the effects of cancer drugs on tumor biology and hence in selecting the proper drugs for the patients in the context of Precision Medicine, the objective of this study is to study the genomic characteristics of ovarian tumors before and after treatment with classic neoadjuvant chemotherapy (NACT) and with the more recently approved PARP inhibitor olaparib.

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Conditions studied

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In context

Ovarian Neoplasms

2,695 studies on the registry are indexed under Ovarian Neoplasms; 727 are open to participants now.

This study's planned enrollment of 50 is below the median of 200 across 527 observational studies indexed under Ovarian Neoplasms.

Browse Ovarian Neoplasms studies →

Lead sponsor

Hellenic Cooperative Oncology Group is the lead sponsor of 58 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
Female
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

women with ovarian cancer eligible for neoadjuvant chemotherapy. The investigators examined changes in tissue molecular profile. The investigators examine tissue molecular profile at diagnosis and after the end of neoadjuvant chemotherapy

Inclusion criteria

  • ovarian cancer eligible for neoadjuvant chemotherapy

Exclusion criteria

Exclusion Criteria:

-

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Study design

Observational model
Other
Time perspective
Retrospective
Enrollment
50 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna
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What researchers measure

Primary outcomes

  1. assesment of genomic characteristics of ovarian tumors at the diagnosis

    Time frame: 4 years

  2. assesment of genomic characteristics of ovarian tumors after treatment with neoadjuvant platinum-based chemotherapy

    Time frame: 4 years

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Study locations

1 of 1 sites recruiting
  • Adamantia Nikolaidi
    Athens, 11524, Greece
    Recruiting
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 1, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04752865
Lead sponsor
Hellenic Cooperative Oncology Group
Responsible party
Sponsor
First posted
Feb 12, 2021
Start date
Feb 9, 2018
Primary completion
Dec 2023 (estimated)
Completion
Jun 2024 (estimated)
Last update
Mar 1, 2023

Study contacts

Adamantia Nikolaidi, MD
Contact
hecogoff@otenet.gr
00302106912520 ext. 12
Maria Moschoni
Contact
m_moschoni@hecog.ondsl.gr
00302106912520 ext. 12
Adamantia Nikolaidi
study chair · HECOG

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.

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