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CompletedNCT04745715Updated Apr 4, 2023

Genomic Study in Non-small Cell Lung Cancer Brain Metastasis

An observational study in NSCLC Stage IV and Brain Metastases, sponsored by National Cheng-Kung University Hospital. Completed at 1 site in Taiwan. Per ClinicalTrials.gov, last updated 2023-04-04.

Sponsored by National Cheng-Kung University Hospital · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
110
Sex
All
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Study summary

The investigators collected the data from the investigators' center between January 2011 and October 2020. The study included all non-small cell lung cancer patients with surgically excised brain metastasis. The investigators analysis the correlation of gene mutation and the disease course.

Read the detailed description

The investigators collected the data from from the investigators' center between January 2011 and October 2020. The study included all non-small cell lung cancer patients with surgically excised brain metastasis. The investigators analysis the correlation of gene mutation and the disease course. The investigators use Kaplan-Meier regression to analyze the overall survival, and the difference between the groups was calculated using log rank test. Cox proportional hazards method was used to create the regression model and estimate the hazard ratios.

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Conditions studied

  • NSCLC Stage IV
  • Brain Metastases
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In context

Carcinoma, Non-Small-Cell Lung

6,645 studies on the registry are indexed under Carcinoma, Non-Small-Cell Lung; 1,665 are open to participants now.

This study's enrollment of 110 is below the median of 164 across 974 observational studies indexed under Carcinoma, Non-Small-Cell Lung.

Browse Carcinoma, Non-Small-Cell Lung studies →

Lead sponsor

National Cheng-Kung University Hospital is the lead sponsor of 276 studies on the registry; 71 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

patients with non-small cell lung cancer underwent craniectomy, who completed postoperative whole brain radiotherapy and associated chemo or target therapy

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

- patients diagnosed with non-small cell lung cancer who underwent craniectomy and subsequent whole brain radiotherapy and associated chemo or target therapy

Exclusion criteria

Exclusion Criteria:

  • patient who did not receive postoperative adjuvant therapy
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
110 participants (actual)
Patient registry
No

Interventions

  • Procedurecraniectomy

    craniectomy outcomes and survival

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What researchers measure

Primary outcomes

  1. postoperative survival

    Time frame: From date of craniectomy until the date of patient deceased or date of last followed medical record, with median follow up around to 20 months

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Study locations

1 site
  • National Cheng Kung University hospital
    Tainan, Taiwan
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 4, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04745715
Responsible party
Sponsor
First posted
Feb 9, 2021
Start date
Jan 1, 2011
Primary completion
Oct 31, 2020
Completion
Oct 31, 2022
Last update
Apr 4, 2023

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2020. You cannot join it, but the record below documents what was studied.

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