An interventional study of Neurophysiology recordings and Neural stimulation in Parkinson Disease, sponsored by Vanderbilt University Medical Center. Recruiting at 1 site in United States. Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2026-06-12.
Sponsored by Vanderbilt University Medical Center · Not applicable, Interventional, and Basic science
The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.
4,487 studies on the registry are indexed under Parkinson Disease; 1,082 are open to participants now.
This study's planned enrollment of 75 is above the median of 40 across 3,294 interventional studies indexed under Parkinson Disease.
Browse Parkinson Disease studies →Vanderbilt University Medical Center is the lead sponsor of 824 studies on the registry; 164 are open to participants now.
Of its 122 completed or terminated interventional studies of FDA-regulated products, 91 (75%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion criteria:
Other: Neurophysiology recordings · Other: Neural stimulation
Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a gambling task evaluated
Neural stimulation will be delivered during a gambling task and its impact on task performance quantified
Changes in caudate DLPFC beta coherence
Caudate DLPFC coherence will be computed at rest and during the gambling task and correlated with cognitive metrics
Time frame: Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours
Changes in gambling task performance with neural stimulation
The gambling task will involve seeing a series of cards presented on the screen and pressing a button to respond with a bet. Gambling task performance will be compared between stimulated and non stimulated blocks and between stimulation targets
Time frame: Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours
Change in beta power with neural stimulation
Beta power will be computed and compared between stimulation on and off conditions for different targets
Time frame: Baseline to end of deep brain stimulation (DBS) surgery, approximately 3-4 hours
Plan to share: No
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Vanderbilt University Medical Center