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CompletedNCT04698707Updated Jan 7, 2021

Role of Supermicrosurgical LVA for Lower Limb Lymphedema

An observational study in Lymphedema, sponsored by Chang Gung Memorial Hospital. Completed at 1 site in Taiwan. Open to participants aged 20 Years to 100 Years. Per ClinicalTrials.gov, last updated 2021-01-07.

Sponsored by Chang Gung Memorial Hospital · Observational

Study type
Observational
Model
Case-control
Time perspective
Retrospective
Enrollment
131
Ages
20 Years to 100 Years
Sex
All
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Study summary

Vascularized lymph node flap transfer (VLNT) was believed to be the treatment of choice for moderate-to-severe lymphedema. Recent publications have supported the use of supermicrosurgical lymphaticovenous anastomosis (LVA) for treating severe lymphedema. This study hypothesizes whether LVA can be performed on post-VLNT patients seeking further improvement.

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Conditions studied

  • Lymphedema

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In context

Lymphedema

560 studies on the registry are indexed under Lymphedema; 135 are open to participants now.

This study's enrollment of 131 is above the median of 106 across 144 observational studies indexed under Lymphedema.

Browse Lymphedema studies →

Lead sponsor

Chang Gung Memorial Hospital is the lead sponsor of 1,064 studies on the registry; 235 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
20 Years to 100 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

From November 2014 to January 2019, a total of 131 lower limb lymphedema patients were enrolled.

Inclusion criteria

  • From November 2014 to January 2019
  • Lower limb lymphedema patients

Exclusion criteria

Exclusion Criteria:

  • Patients who have had previous LVA, liposuction, or excisional therapy such as the Charles procedure were excluded.
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Study design

Observational model
Case-control
Time perspective
Retrospective
Enrollment
131 participants (actual)
Patient registry
No

Groups and cohorts

  • lower limb lymphedema patients

    This retrospective cohort study enrolled 131 lower limb lymphedema patients including 10 patients who have received VLNT as their primary lymphedema surgery showing minimal post-VLNT improvement (Group I) and 121 patients without previous lymphatic surgery (Group II).

    Other: Vascularized lymph node flap transfer · Other: Patients without prior lymphedema surgery

Interventions

  • OtherVascularized lymph node flap transfer

    Patients who have received VLNT as their primary treatment but with minimal improvement

  • OtherPatients without prior lymphedema surgery

    Patients without prior lymphedema surgery

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What researchers measure

Primary outcomes

  1. Magnetic resonance volumetry

    Magnetic resonance volumetry was used for measuring preoperative and postoperative volume changes at least 6-month after LVA.

    Time frame: 6 months after LVA

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Study locations

1 site
  • Kaohsiung Chang Gung Memorial Hospital
    Kaohsiung, 83301, Taiwan
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 7, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04698707
Lead sponsor
Chang Gung Memorial Hospital
Responsible party
Sponsor
First posted
Jan 7, 2021
Start date
Aug 28, 2020
Primary completion
Oct 5, 2020
Completion
Nov 19, 2020
Last update
Jan 7, 2021

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2021. You cannot join it, but the record below documents what was studied.

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