An observational study in Anesthesia; Adverse Effect and Cesarean Section Complications, sponsored by Mahidol University. Completed at 1 site in Thailand. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-04-11.
Sponsored by Mahidol University · Observational
The aim of this study is to reveal the factor associated with failed spinal anaesthesia in cesarean delivery. We conduct the retrospective case-control study to elucidate the involving factors.
Spinal anaesthesia is the anaesthetic technique of choice of patients undergoing cesarean delivery due to its rapid onset, good reliability and good efficacy. However, the inadequate or failed spinal anaesthesia can occur. The previous literatures revealed incidence of failed spinal anaesthesia was as high as 0.5-6%. Failure of spinal anaesthesia leads to numerous maternal and neonatal consequences. Those failed spinal anaesthesia patients required general anaesthesia with endotracheal tube which may cause several complications such as hypoxia, difficult intubation, failed intubation and pulmonary aspiration. Also, a recent network meta-analysis showed general anaesthesia decreasing neonatal Apgar score.
The factors that associated with failed spinal anaesthesia in cesarean delivery has been studied. The amount of local anaesthetic, needle type, patients' body mass index (obesity), and experiences of the anaesthetist performing spinal block influenced the failure of spinal anaesthesia. The details and factors of failed spinal anaesthesia in our hospital was scarce. It has not yet been published in the literature.
Therefore, the aim of this study is to reveal the factor associated with failed spinal anaesthesia in cesarean delivery. We conduct the retrospective case-control study to elucidate the involving factors.
Mahidol University is the lead sponsor of 731 studies on the registry; 116 are open to participants now.
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Pregnant women who gestational age > 24 weeks and patient age more than or equal to 18 years, undergoing cesarean delivery and received spinal anaesthesia.
Exclusion Criteria:
Failed spinal anaesthesia: failure of anaesthetic level of blockade both sensory and motor blockage, and consequently receive general anaesthesia
Procedure: spinal anaesthesia with local anaesthetic and intrathecal morphine
Patient receiving spinal anaesthesia and successfully finish the cesarean section
Procedure: spinal anaesthesia with local anaesthetic and intrathecal morphine
Patients undergoing cesarean delivery and received spinal anaesthesia with local anaesthetic and intrathecal morphine
Age
Factors involving failed spinal anaesthesia for cesarean delivery: patient age
Time frame: At starting operation
Body mass index
Factors involving failed spinal anaesthesia for cesarean delivery: patient body mass index (BMI) : weight and height will be combined to report BMI in kg/m\^2
Time frame: At starting operation
Anaesthesiologist performing spinal anaesthesia
Factors involving failed spinal anaesthesia for cesarean delivery: Anaesthesiologist performing spinal anaesthesia (resident or consultant)
Time frame: At starting anaesthesia
Time starting of operation
Factors involving failed spinal anaesthesia for cesarean delivery: at which time cesarean delivery starting to performed eg. in office hour or out of office hour
Time frame: At starting operation
Incidence of failed spinal anaesthesia for cesarean delivery
Incidence of failed spinal anaesthesia for cesarean delivery
Time frame: At starting operation
Plan to share: Undecided — The plan to make individual participant data (IPD) available to other researchers was undecided
This study is completed, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.
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Mahidol University